Evaluation of some humoral immune system parameters in beta Thalassemia major patients at Wasit Province Iraq

Abstract EN

The present study aimed to investigate the humeral immunity in Beta Thalassemia Major (BTM) patients by measure the serum levels of immunoglobulins (IgM), (IgG), (IgA), and complement system (C3, C4).

A total of 80 BTMpatients were enrolled in the study their age ranged between (6-25) years .The patients were subdivided according to their age into three age groups.

The most predominant age group was 11-20 years 38:80 (47.5%).

While the patients below 10 years were 29:80(36.25%) and more than 20 years 13:80 (16.25%).It has been shown through a questionnaire thatall patients more than 20 years were splenectomies patients.

In comparison with 45 ages matched healthy control groups there were a significant increase (p ≤ 0.05)in serum IgM, IgG, and IgA in all groups of BTM patients.

The serum levels of immunoglobulins M,G,and A increased significantly (p ≤ 0.05) with age in BTM patients.

Serum C3and C4 decreased significantly in all groups of BTM patients compared with age matched healthy control.

It has been observed that sreum C3 reduced in 11-20 years a and more than 20 years BTM patients age groups compared with patients below 10 years، whereas no significant difference in serum C4 among BTM patients age groups when compared with each other.