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Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide
Joint Authors
Yunus, Samar Jalal
Khidr, Rasha Abd al-Ghani
al-Sharbaji, Safinaz Hamid
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 28, Issue 1 (31 Mar. 2016), pp.23-30, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : O6-methylguanine-DNA methyltransferase (MGMT) protein expression using immunohistochemical analysis was proposed as a prognostic marker for patients with newly diagnosed glioblastoma (GBM) treated with radiation therapy with concurrent and adjuvant Temozolomide (TMZ).
Methods : From April 2012 to October 2014, 73 patients with newly diagnosed GBM, MGMT protein expression were analyzed in formalin-fixed, paraffin-embedded tumor specimens.
Patients received the radiation therapy plus concomitant and adjuvant TMZ chemotherapy.
Results : For the whole cohort, the median overall survival (OS) was 15 months, and the progression-free survival was 10 months.
Patients who had low MGMT protein expression (615%) had a significantly improved OS and PFS compared with patients who had high MGMT expression (17.0 months vs 14 months; P value .006) and (15.0 months vs 10 months; P value .016) respectively.
The age and extent of tumor resection were the strongest clinical predictors of outcome.
In multivariate Cox models MGMT protein expression, extent of tumor resection and age were identified as independent prognostic factors.
American Psychological Association (APA)
Yunus, Samar Jalal& Khidr, Rasha Abd al-Ghani& al-Sharbaji, Safinaz Hamid. 2016. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 1, pp.23-30.
https://search.emarefa.net/detail/BIM-667818
Modern Language Association (MLA)
Yunus, Samar Jalal…[et al.]. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute Vol. 28, no. 1 (Mar. 2016), pp.23-30.
https://search.emarefa.net/detail/BIM-667818
American Medical Association (AMA)
Yunus, Samar Jalal& Khidr, Rasha Abd al-Ghani& al-Sharbaji, Safinaz Hamid. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 1, pp.23-30.
https://search.emarefa.net/detail/BIM-667818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 21-22
Record ID
BIM-667818