Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT)‎ protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide

Joint Authors

Yunus, Samar Jalal
Khidr, Rasha Abd al-Ghani
al-Sharbaji, Safinaz Hamid

Source

Journal of the Egyptian National Cancer Institute

Issue

Vol. 28, Issue 1 (31 Mar. 2016), pp.23-30, 8 p.

Publisher

Cairo University National Cancer Institute

Publication Date

2016-03-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Topics

Abstract EN

Background : O6-methylguanine-DNA methyltransferase (MGMT) protein expression using immunohistochemical analysis was proposed as a prognostic marker for patients with newly diagnosed glioblastoma (GBM) treated with radiation therapy with concurrent and adjuvant Temozolomide (TMZ).

Methods : From April 2012 to October 2014, 73 patients with newly diagnosed GBM, MGMT protein expression were analyzed in formalin-fixed, paraffin-embedded tumor specimens.

Patients received the radiation therapy plus concomitant and adjuvant TMZ chemotherapy.

Results : For the whole cohort, the median overall survival (OS) was 15 months, and the progression-free survival was 10 months.

Patients who had low MGMT protein expression (615%) had a significantly improved OS and PFS compared with patients who had high MGMT expression (17.0 months vs 14 months; P value .006) and (15.0 months vs 10 months; P value .016) respectively.

The age and extent of tumor resection were the strongest clinical predictors of outcome.

In multivariate Cox models MGMT protein expression, extent of tumor resection and age were identified as independent prognostic factors.

American Psychological Association (APA)

Yunus, Samar Jalal& Khidr, Rasha Abd al-Ghani& al-Sharbaji, Safinaz Hamid. 2016. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 1, pp.23-30.
https://search.emarefa.net/detail/BIM-667818

Modern Language Association (MLA)

Yunus, Samar Jalal…[et al.]. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute Vol. 28, no. 1 (Mar. 2016), pp.23-30.
https://search.emarefa.net/detail/BIM-667818

American Medical Association (AMA)

Yunus, Samar Jalal& Khidr, Rasha Abd al-Ghani& al-Sharbaji, Safinaz Hamid. Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant temozolomide. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 1, pp.23-30.
https://search.emarefa.net/detail/BIM-667818

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 21-22

Record ID

BIM-667818