دور Bcl-2 المصلي في سرطان الثدي الناكس

Abstract EN

Recurrence is a major problem which affects 40% of Breast cancer patients.

Bcl-2 is an anti-apoptotic protein, which is implicated in many cases of cancer development and cancer resistance to therapy.

In this study we investigate the role of Bcl-2 in recurrence in Breast cancer patients.

Blood samples were collected from 25 healthy individuals (control) and from 60 primary Breast cancer patients.

The serum samples were analyzed for measurement of Bcl-2, ANAs and anti-dsDNA antibodies using ELISA techniques.

There was elevation in the serum levels of Bcl-2 in breast cancer patients, comparing to healthy controls, and there was significant elevation in Bcl-2 levels in patients suffering from recurrence.

In addition, patients with higher levels of Bcl-2 had decreased titer of auto-antibodies, comparing to patients with lower levels of Bcl-2.

We found that there is a role of Bcl-2 in Breast cancer recurrence, and that may be due to its negative effect on auto-antibodies production.