دراسة المستقبل II الذواب لعامل النخر الورمي ألفا لدى سوريين مصابين بفشل القلب

Abstract EN

Cytokines play an important role in the deterioration of cardiac injury.

Tumor necrosis factor α (TNF α) is one of these cytokines.

It is cytokine secreted by many immune cells and leads to the progression of heart failure (HF), by binding to receptors on the heart (TNF-R1 and TNF-R2), which stimulates apoptosis of myocardial cells.

For this, our research aimed to study the serum levels of soluble receptor II of tumor necrosis factor alpha (sTNFα RII) and TNFα in patients with heart failure, and its relation with the severity of disease and advanced cardiac dysfunction.

Serum levels of the soluble receptor II of tumor necrosis factor alpha and tumor necrosis factor alpha were measured in 60 patients with heart failure and 28 apparently healthy subjects (control group).

According to the classification of the New York Heart Association (NYHA), patients were clinically classified to the following groups: NYHAI (3 patients), NYHAII (23 patients) NYHAIII (28 patients), NYHAIV (6 patients).

This study showed that the serum levels of soluble receptor II of tumor necrosis factor alpha (sTNFαRII) were significantly elevated (p<0.0001) in patients with heart failure, compared with the control group (3360.34±122.09 pg/ ml and 1383.53±72.05 pg/ ml.

respectively).

Serum levels of soluble receptor II of tumor necrosis factor alpha significantly increased (p=0.0001) in parallel with disease progression.

Serum levels of tumor necrosis factor alpha were significantly elevated (p<0.0001) in patients with heart failure, compared with control group (4.46±0.09 pg/ ml and 1.15±0.17 pg/ml, respectively) Serum TNFα levels were significantly higher (p<0.0001) in NYHAIII patients (mean±SE: 4.93±0.1 pg/ml) than in NYHAII patients (mean±SE: 3.87±0.07 pg/ml), but these levels did not increased significantly (p=1.0) in NYHAIV than in NYHAIII patients.

As conclusion, sTNFαRII is better predictor of advanced heart failure (NYHAIV) than TNFα.