Synthesis and cytotoxic effect on RD cell line of Pd (II) and Cu (II)
Joint Authors
Shakir, Carolin
Muhammad, Faruq I.
Ilyas, Mahasin Faysal Ahmad
Yusuf, Imad
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 1 (31 Jan. 2016), pp.24-32, 9 p.
Publisher
Publication Date
2016-01-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Complexes of Cr(III), Cd(II), Ni(II), Pd(II) and Cu(II) with new ligand sodium [5-(pnitro phenyl)-/4-phenyl-1,2,4-triazole-3-dithiocarbamato hydrazide] (TRZ.DTC) have been prepared and characterized in solid state by using flame atomic absorption, elemental analysis C.H.N.S, FT-IR, UV–vis spectrophotometry, thermal analysis TGA, conductivity and magnetic susceptibility measurements.
The ratio of M:L and logK was determined by molar ratio method.
From the spectral studies, an octahedral monomer structure was proposed for all complexes except copper(II) which has a dimeric structure.
Cadmium(II) has tetrahedral geometry.
Structural geometries of these compounds were also suggested in gas phase by using hyper chem-8 program.
The heat of formation, binding energy, and dipole moment were calculated by PM3 and ZINDO/1 methods.
ZINDO/1 was used to evaluate the vibration spectra of the (TRZ.DTC) ligand and starting material as authentic compound.
Cytotoxic effect of Pd, Cu and ligand was evaluated against Rhabdomyosarcoma cell line by using four different concentrations (500, 250, 125 & 62.5 lg/ml) in three exposure times 24, 48 and 72 h and compared this effect with control positive Cis-Pt.
The efficiency of these new compounds on RD cell line may be attributed to blocking the protein synthesis of the cells.
American Psychological Association (APA)
Ilyas, Mahasin Faysal Ahmad& Shakir, Carolin& Muhammad, Faruq I.& Yusuf, Imad. 2016. Synthesis and cytotoxic effect on RD cell line of Pd (II) and Cu (II). Journal of Saudi Chemical Society،Vol. 20, no. 1, pp.24-32.
https://search.emarefa.net/detail/BIM-668224
Modern Language Association (MLA)
Ilyas, Mahasin Faysal Ahmad…[et al.]. Synthesis and cytotoxic effect on RD cell line of Pd (II) and Cu (II). Journal of Saudi Chemical Society Vol. 20, no. 1 (Jan. 2016), pp.24-32.
https://search.emarefa.net/detail/BIM-668224
American Medical Association (AMA)
Ilyas, Mahasin Faysal Ahmad& Shakir, Carolin& Muhammad, Faruq I.& Yusuf, Imad. Synthesis and cytotoxic effect on RD cell line of Pd (II) and Cu (II). Journal of Saudi Chemical Society. 2016. Vol. 20, no. 1, pp.24-32.
https://search.emarefa.net/detail/BIM-668224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 31-32
Record ID
BIM-668224