دراسة مستويات الكادميوم لدى المدخنين من مرضى سرطان الرئة و مرضى الفشل الكلوي المزمن

Abstract EN

Cadmium (Cd) is a heavy metal, found as an environmental contaminant, both through natural and industrial sources.

Many studies showed that people may expose to Cadmium from smoking the cigarettes, which are the main sources.

Cadmium has a long biological half-life ranging from 10 to 30 years.

Cadmium is primarily toxic to the kidney, it accumulates over time and may cause renal dysfunction.

The International Agency for Research on Cancer has classified Cadmium as a human carcinogen (Group 1).

Newer data on human exposure to cadmium in the general population have been statistically associated with increased risk of lung cancer, since Cadmium interferes with various important metabolic mechanisms.

In this study, The Graphite furnace Atomic Absorption Spectrometry (GFAAS) was used to detect Cadmium levels, and The ELISA technique to evaluate the protein ß2M and Alpha-Fetoprotein (AFP) in serum of 126 subjects (40 lung cancer smoked patients, 40 smoked chronic renal failure, 23 smoked healthy subjects and 23 non smoked healthy subjects).

The present findings suggest that there is an increase in serum cadmium levels of smoked patients with lung cancer and chronic renal failure, more than smoked and non-smoked healthy subjects.

However, protein ß2M levels were higher in the serum of smokers with chronic renal failure, more than smokers of lung cancer patients and healthy smokers and non-smokers.

In this study, no correlation was reported between Cd and AFP levels.