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Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation
Joint Authors
Narayana, Badiadka
Ismail, Nisrin Bani Shaykh
Divya, Kumble
Source
Arab Journal of Basic and Applied Sciences
Issue
Vol. 19, Issue 0 (29 Feb. 2016), pp.8-14, 7 p.
Publisher
University of Bahrain College of Science
Publication Date
2016-02-29
Country of Publication
Bahrain
No. of Pages
7
Main Subjects
Abstract EN
Two simple and selective visible spectrophotometric methods were developed for assay of bifonazole in pure drug and in its pharmaceutical formulation.
The developed methods were based on the charge transfer complexation reaction of bifonazole with 2,5-dichloro-3,6-dihydroxy- 1,4-benzoquinone (CAA) for method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) for method B, resulting in the formation of colored complex.
The colored reaction products were quantitated spectrophotometrically at 517 nm and 457 nm for bifonazole-CAA and bifonazole- DDQ complexes, respectively.
The complexes obeyed Beer’s law in the concentration range of 50.00–400.00 and 5.00–50.00 lg mL1 with molar absorptivities at 0.0956 · 104 and 0.6953 · 104 L mol1 cm1 for method A and method B, respectively.
The proposed procedures were successfully applied for the quantitative determination of bifonazole in its pharmaceutical formulation.
The solid charge transfer complexes of bifonazole with each of the p-acceptor reagent were also synthesized and characterized by FT-IR spectroscopy.
American Psychological Association (APA)
Ismail, Nisrin Bani Shaykh& Narayana, Badiadka& Divya, Kumble. 2016. Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation. Arab Journal of Basic and Applied Sciences،Vol. 19, no. 0, pp.8-14.
https://search.emarefa.net/detail/BIM-668396
Modern Language Association (MLA)
Ismail, Nisrin Bani Shaykh…[et al.]. Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation. Arab Journal of Basic and Applied Sciences Vol. 19 (Feb. 2016), pp.8-14.
https://search.emarefa.net/detail/BIM-668396
American Medical Association (AMA)
Ismail, Nisrin Bani Shaykh& Narayana, Badiadka& Divya, Kumble. Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation. Arab Journal of Basic and Applied Sciences. 2016. Vol. 19, no. 0, pp.8-14.
https://search.emarefa.net/detail/BIM-668396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14
Record ID
BIM-668396