A novel spectrophotometric approach for the determination of febantel in pure and dosage forms

Abstract EN

A new, simple, accurate and rapid spectrophotometric method was developed for the quality control of febantel (FBT), in pure and dosage forms.

The method was based on the utility of p-acceptors such as 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (CAA) or 2,3-dichloro-5,6-dicyano- p-benzoquinone (DDQ) for the determination of FBT which act as an e-donor to form a highly colored complex with absorption bands at 524 and 579 nm, respectively.

The applicability of the method was demonstrated by the determination of the studied drug in commercial tablets and the results were statistically evaluated as per the ICH guidelines.

The new spectrophotometric method described in this paper is fast, convenient and has the novelty of carrying out the quantitative determination of FBT in pure and dosage forms.