Blockade of pge2, pgd2 receptors confers protection against prepatent schistosomiasis Mansoni in mice
Joint Authors
Naji, Fatin M.
al-Ahwani, Iman G.
Abd al-Ghani, Rasha
Rabiah, Ibrahim
Sabir, Samih
Ula, Mahmud
Hamid, Rabab Salim
Barakat, Walid
al-Jamal, Rasha H.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 45, Issue 3 (31 Dec. 2015), pp.511-520, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Schistosomiasis is a chronic disease with considerable social impact.
Despite the availability of affordable chemotherapy, drug treatment has not significantly reduced the overall number of disease cases.
Among other mechanisms, the parasite produces PGE2 and PGD2 to evade host immune defenses.
To investigate the role of PGE2 and PGD2 in schistosomiasis, we evaluated the effects of L-161,982, Ah6809 (PGE2 receptor antagonists alone or combined with each other) and MK-0524 (PGD2 receptor antagonist) during prepatent Schistosoma mansoni infection.
Drugs were administered intraperitoneally an hour before and 24 hours after infection of C57BL/6 mice with 100 Schistosoma mansoni cercariae.
L-161,982, Ah6809, their combination and MK-0524 caused partial protection against pre-patent S.
mansoni infection which was mediated by biasing the immune response towards Th1 phenotype.
These results showed that blockade of PGE2 and PGD2 receptors confers partial protection against pre-patent S.
mansoni infection in mice and that they may be useful as adjunctive therapy to current anti-schistosomal drugs or vaccines
American Psychological Association (APA)
Abd al-Ghani, Rasha& al-Ahwani, Iman G.& Sabir, Samih& al-Jamal, Rasha H.& Naji, Fatin M.& Hamid, Rabab Salim…[et al.]. 2015. Blockade of pge2, pgd2 receptors confers protection against prepatent schistosomiasis Mansoni in mice. Journal of the Egyptian Society of Parasitology،Vol. 45, no. 3, pp.511-520.
https://search.emarefa.net/detail/BIM-668473
Modern Language Association (MLA)
al-Ahwani, Iman G.…[et al.]. Blockade of pge2, pgd2 receptors confers protection against prepatent schistosomiasis Mansoni in mice. Journal of the Egyptian Society of Parasitology Vol. 45, no. 3 (Dec. 2015), pp.511-520.
https://search.emarefa.net/detail/BIM-668473
American Medical Association (AMA)
Abd al-Ghani, Rasha& al-Ahwani, Iman G.& Sabir, Samih& al-Jamal, Rasha H.& Naji, Fatin M.& Hamid, Rabab Salim…[et al.]. Blockade of pge2, pgd2 receptors confers protection against prepatent schistosomiasis Mansoni in mice. Journal of the Egyptian Society of Parasitology. 2015. Vol. 45, no. 3, pp.511-520.
https://search.emarefa.net/detail/BIM-668473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 518-520
Record ID
BIM-668473