Concomitant accelerated hyper-fractionated radiotherapy and temozolmide in the treatment of high grade astrocytoma
Joint Authors
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 14, Issue 1 (31 Mar. 2002), pp.9-15, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2002-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Purpose : to evaluate the safety and efficacy of accelerated hyper-fractionated radiotherapy combined with tem-ozolomide in patients with high grade astrocytoma.
Methods and materials : Twenty-four patients with newly diagnosed and histologically proven high grade as-trocytoma were enrolled into this study.
Treatment protocol included radiotherapy delivered in fractions of 150 cGy 3 times daily with at least 4-hour intervals between fractions to a total dose 4050 cGy.
The target volume was the tumor plus the edema with a 2-cm margin.
A boost of 1800 cGy was given to the tumor plus a 2-cm margin to a total dose of 5850 cGy delivered in 39 sessions over 2.5 weeks.
Temozolomide dose was (150 mg / m2 / dayx7d / wk) given 2 hours prior to radiotherapy, from the beginning till the end of the course.
Results : of the 24 patients included 5 (21 %) developed G2 and G3 neutropenia, and 4 patients (17 %) developed G2 and G3 thrombocytopenia.
Non-hematologic toxic-ities were : G2 and G3 vomiting in 8 (33 %) patients, G2 and G3 fatigue in 13 (54 %) patients, G2 skin rash in 4 (17 %), and G2 acute radiation reaction in 2 (8 %) patients.
The twelve months and 18 months survival rates were 67 % and 51.5 % respectively.
Patients aged < 45 years and those who underwent debulking surgery had better survival rates (69 % and 70 %) in comparison to those aged ≥ 45 years and those who underwent biopsy only (27 % and 36 %).
Conclusion : temozolomide in a daily dose of 150 mg/ m2 concomitant with thrice daily fractions of 150 cGy for a total dose of 5840 cGy is a safe and tolerable regimen in terms of acute toxicities, however long term follow-up is required for proper assessment of late toxicities.
The results achieved are promising and need to be confirmed in a randomized trial comparing accelerated hyper-fractionated radiotherapy with and without temozolomide.
American Psychological Association (APA)
Hashim, Tariq& Tantawi, Amir. 2002. Concomitant accelerated hyper-fractionated radiotherapy and temozolmide in the treatment of high grade astrocytoma. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 1, pp.9-15.
https://search.emarefa.net/detail/BIM-66881
Modern Language Association (MLA)
Hashim, Tariq& Tantawi, Amir. Concomitant accelerated hyper-fractionated radiotherapy and temozolmide in the treatment of high grade astrocytoma. Journal of the Egyptian National Cancer Institute Vol. 14, no. 1 (Mar. 2002), pp.9-15.
https://search.emarefa.net/detail/BIM-66881
American Medical Association (AMA)
Hashim, Tariq& Tantawi, Amir. Concomitant accelerated hyper-fractionated radiotherapy and temozolmide in the treatment of high grade astrocytoma. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 1, pp.9-15.
https://search.emarefa.net/detail/BIM-66881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-15
Record ID
BIM-66881