The cardioprotective effect of selenium in myocardial ischemia reperfusion injury
Joint Authors
al-Shaybani, Basim Irhim Muhammad
al-Umran, Fadil G.
al-Turfi, Muhammad N. H.
al-Hulw, Mahdi S.
Source
Kufa Journal for Veterinary Medical Sciences
Issue
Vol. 6, Issue 2 (31 Dec. 2015), pp.128-135, 8 p.
Publisher
University of Kufa Faculty of Veterinary Medicine
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The objective of the current study is to assess the possible cardioprote-ctive effect of selenium in myocardial ischemia reperfusion injury induced by ligation of coronary artery in a male rat model.
24 adult male sprague dawley rats were randomized into 4 equal groups: (1), Sham group, rats underwent the same anesthetic and surgical procedures as the control group except for LAD ligation; (2), Active control group, rats subjected to regional ischemia for 30 min by ligation of LAD coronary artery and reperfusion for 2 hours; (3), Control vehicle group, rats received D.W (vehicle of selenium) via IP route and subjected to ischemia for 30 minutes before ligation of LAD coronary artery & reperfusion for 2 hr; (4), Seleniumtreated group, rats pretreated with selenium5mg/kg via IP injection 30minutes before ligation of LAD coronary artery & then subjected to reperfusion for 2 hr.
In control group, as compared with sham, tissue TNF-α, IL-6, IL-10, caspase-3 and BAX, plasma cTn-T and serum MDA significantly increased (P<0.05), while serum GSH significantly decreased (P<0.05).
Histopathologically, control group showed a significant cardiac injury (P<0.05) compared with sham group.
Selenium significantly counteracted (P<0.05) the increase of TNF-α, IL-6, caspase-3 and BAX and counteracted the increase in plasma cTn-T and serum MDA.
Selenium produces a significant elevation (P<0.05) in cardiac IL-10 and serum GSH with significant reduction in (P<0.05) cardiac injury.
In Conclusions, Selenium minimizes myocardial I/R injury in male rats via interfering with inflammatory reactions and apoptosis which were induced by I / R injury .
American Psychological Association (APA)
al-Shaybani, Basim Irhim Muhammad& al-Umran, Fadil G.& al-Turfi, Muhammad N. H.& al-Hulw, Mahdi S.. 2015. The cardioprotective effect of selenium in myocardial ischemia reperfusion injury. Kufa Journal for Veterinary Medical Sciences،Vol. 6, no. 2, pp.128-135.
https://search.emarefa.net/detail/BIM-673949
Modern Language Association (MLA)
al-Shaybani, Basim Irhim Muhammad…[et al.]. The cardioprotective effect of selenium in myocardial ischemia reperfusion injury. Kufa Journal for Veterinary Medical Sciences Vol. 6, no. 2 (2015), pp.128-135.
https://search.emarefa.net/detail/BIM-673949
American Medical Association (AMA)
al-Shaybani, Basim Irhim Muhammad& al-Umran, Fadil G.& al-Turfi, Muhammad N. H.& al-Hulw, Mahdi S.. The cardioprotective effect of selenium in myocardial ischemia reperfusion injury. Kufa Journal for Veterinary Medical Sciences. 2015. Vol. 6, no. 2, pp.128-135.
https://search.emarefa.net/detail/BIM-673949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 135
Record ID
BIM-673949