Study some of the histopathological changes of acute, subacute and chronic lead acetate toxicity related to catalase activity in blood of adult male wistar rats

Abstract EN

The present work was aimed to study the histopathological changes due to lead acetate intoxication and measure the activity of catalase in the serum of adult male rats.

Sixty male rats aged (8) weeks and weight (45-60) gm were divided equally into (4) groups as follows: Group I: Rats served as control (C) and received distilled water for 3 months.

Group II: Rats served as experimental and received by gavage lead acetate diluted in distlled water at 100 mg/kg B.W.

/day for 1 month.

Group III: Rats served as experimental and received by gavage lead acetate diluted in distlled water at 100 mg/kg B.W.

/day for 2 month.

Group IV: Rats served as experimental and received by gavage lead acetate diluted in distlled water at 100 mg/kg B.W.

/day for 3 month.

Blood samples were collected by cardiac puncture to estimate serum catalase activity.

Specimens from brain, liver, kidneys, urinary bladder and spleen, were dissected out for histopathological examination.

Results should time dependent significant decrease in serum catalase activity with toxicopathological changes in the targeted organs, the severity of the changes depend on time of exposure, with hyperplasia of urinary bladder.

From the above results, it was concluded that lead acetate intoxication lead to significant decrease in serum catalase activity with toxicopathological changes in the targeted organs, these changes were time dependent.