Formulation and evaluation of ezetimibe nanoparticles
Other Title(s)
تصييغ و تقييم حبيبات الأزيتيميب بواسطة الجسيمات النانوية
Joint Authors
Ali, Yasir Abd al-Sahib
Abd al-Hamid, Shayma Nizar
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 24, Issue 2 (31 Dec. 2015), pp.11-21, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
The aim of this study is to formulate and evaluate ezetimibe nanoparticles using solvent antisolvent technology.
Ezetimibe is a practically water-insoluble drug which acts as a lipid lowering drug that selectively inhibits the intestinal absorption of cholesterol and related phytosterols.
Ezetimibe prepared as nano particles in order to improve its solubility and dissolution rate.
Thirty formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl pyrrolidone (PVPK-30), poly vinyl alcohol (PVA), hydroxy propyl methyl cellulose E5 (HPMC), and poloxamer.
The ratios of drug to stabilizers used to prepare the nanoparticles were 1 : 2, 1 : 3 and 1:4.
The prepared nanoparticles were evaluated for particle size, entrapment efficiency, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and atomic force microscopy.
The percentage of drug entrapment efficiency of F1-F30 was ranged from 85 % ± 1 to 98 % ± 1.
On the other hand dissolution rate increasing as the particle surface area is increase due to reduction of particle size to the nano range.
The results showed that poly vinyl pyrrolidone (PVPK-30) was found to be the best stabilizer.
American Psychological Association (APA)
Ali, Yasir Abd al-Sahib& Abd al-Hamid, Shayma Nizar. 2015. Formulation and evaluation of ezetimibe nanoparticles. Iraqi Journal of Pharmaceutical Sciences،Vol. 24, no. 2, pp.11-21.
https://search.emarefa.net/detail/BIM-674063
Modern Language Association (MLA)
Ali, Yasir Abd al-Sahib& Abd al-Hamid, Shayma Nizar. Formulation and evaluation of ezetimibe nanoparticles. Iraqi Journal of Pharmaceutical Sciences Vol. 24, no. 2 (Dec. 2015), pp.11-21.
https://search.emarefa.net/detail/BIM-674063
American Medical Association (AMA)
Ali, Yasir Abd al-Sahib& Abd al-Hamid, Shayma Nizar. Formulation and evaluation of ezetimibe nanoparticles. Iraqi Journal of Pharmaceutical Sciences. 2015. Vol. 24, no. 2, pp.11-21.
https://search.emarefa.net/detail/BIM-674063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20-21
Record ID
BIM-674063