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Preparation and characterization of montelukast sodium (SMLT) as a dual sustained release buccal strips
Other Title(s)
تحضير و تشخيص المونتيلوكاست صوديوم كشرائح فموية مزدوجة بطيئة التحرر
Author
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 24, Issue 2 (31 Dec. 2015), pp.61-71, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
An oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting method .
The results obtained by this study revealed ,that best fast dissolving film of SMLT was loaded in carrageenan polymer 57 % w\w (30mg.) , with acceptable physical properties, like film thickness , elastic endurance and surface pH .
Besides to that , the disintegration time , and cumulative 80% drug release were estimated 22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 ) as a second layer , appear to be the most promised layer of SMLT loaded in 50 % w\w (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH .
Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release was 15 minutes extended for 4hours of 100% drug release .
Meanwhile , the investigation of possible interference between the drug , and, polymers used revealed no evidence of this effect ,using FTIR , and SEM technique .
In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet as a marketed product was used , the result gave more than 4 hours of selected formula , compared with 30 minutes to marketed product Singulair® .
The overall results candidates the selected FSR6-7 formula as a promised bi layer buccal fast , as compliance and extended therapy for asthmatic mid- night patients.
American Psychological Association (APA)
Khalil, Yahya I.. 2015. Preparation and characterization of montelukast sodium (SMLT) as a dual sustained release buccal strips. Iraqi Journal of Pharmaceutical Sciences،Vol. 24, no. 2, pp.61-71.
https://search.emarefa.net/detail/BIM-674078
Modern Language Association (MLA)
Khalil, Yahya I.. Preparation and characterization of montelukast sodium (SMLT) as a dual sustained release buccal strips. Iraqi Journal of Pharmaceutical Sciences Vol. 24, no. 2 (Dec. 2015), pp.61-71.
https://search.emarefa.net/detail/BIM-674078
American Medical Association (AMA)
Khalil, Yahya I.. Preparation and characterization of montelukast sodium (SMLT) as a dual sustained release buccal strips. Iraqi Journal of Pharmaceutical Sciences. 2015. Vol. 24, no. 2, pp.61-71.
https://search.emarefa.net/detail/BIM-674078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 70-71
Record ID
BIM-674078