![](/images/graphics-bg.png)
Potentiometric transducers for the selective recognition of risperidone based on molecularly imprinted polymer
Other Title(s)
متحسسات جهدية للتعيين الانتقائي للرسبيريدون المعتمد على بوليمرات الطبعة الجزيئية
Joint Authors
Yasin, Hamsah Munim
Abd Allah, Najwa Ishaq
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 24, Issue 2 (31 Dec. 2015), pp.30-40, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
Graphite Coated Electrodes (GCE) based on molecularly imprinted polymers were fabricated for the selective potentiometric determination of Risperidone (Ris).
The molecularly imprinted (MIP) and nonimprinted (NIP) polymers were synthesized by bulk polymerization using (Ris.) as a template, acrylic acid (AA) and acrylamide (AAm) as monomers, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide (BPO) as an initiator.
The imprinted membranes and the non-imprinted membranes were prepared using dioctyl phthalate (DOP) and Dibutylphthalate (DBP) as plasticizers in PVC matrix.
The membranes were coated on graphite electrodes.
The MIP electrodes using (AA) and (AAm) showed a near nernstian and nernstian response with slopes of 55.2 ± 0.1 and 59.0±0.2 mV/decade, correlation coefficient (r2) 0.9997 and 0.9999, a linear response for a concentration range of (1.0 × 10-6 - 1.0 × 10-2) M and (5.0x 10-7 to 1.0 x 10-2) M respectively.
The response time of the prepared electrodes was less than 30 seconds.
The electrode responses were stable in a pH range (4-8).
The electrodes exhibited good selectivity over a wide range of interference.
The most effective electrode (Ris-MIP GCE) was used to determine the concentration of (Ris.) in some pharmaceutical formulations.
The electrodes could be successfully used within (7and13) weeks respectively without any drift.
American Psychological Association (APA)
Abd Allah, Najwa Ishaq& Yasin, Hamsah Munim. 2015. Potentiometric transducers for the selective recognition of risperidone based on molecularly imprinted polymer. Iraqi Journal of Pharmaceutical Sciences،Vol. 24, no. 2, pp.30-40.
https://search.emarefa.net/detail/BIM-674094
Modern Language Association (MLA)
Abd Allah, Najwa Ishaq& Yasin, Hamsah Munim. Potentiometric transducers for the selective recognition of risperidone based on molecularly imprinted polymer. Iraqi Journal of Pharmaceutical Sciences Vol. 24, no. 2 (Dec. 2015), pp.30-40.
https://search.emarefa.net/detail/BIM-674094
American Medical Association (AMA)
Abd Allah, Najwa Ishaq& Yasin, Hamsah Munim. Potentiometric transducers for the selective recognition of risperidone based on molecularly imprinted polymer. Iraqi Journal of Pharmaceutical Sciences. 2015. Vol. 24, no. 2, pp.30-40.
https://search.emarefa.net/detail/BIM-674094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39-40
Record ID
BIM-674094