Serum transferrin receptor in relation to iron status in different disease stage of adult malignant lymphoma
Joint Authors
Hindawi, Dalia
Aql, Samiyah
Abd al-latif, Nahlah A.
al-Attar, Inas
al-Mahallawy, Haydar Ahmad
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 14, Issue 3 (30 Sep. 2002), pp.237-242, 6 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2002-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Soluble transferrin receptor is a new diagnostic tool for determining iron status and erythropoietic activity.
The objective of this study was to evaluate the diagnostic efficiency of serum soluble transferrin receptor (sTfR) measurements together with the estimation of bone marrow iron stores in different phases of non-Hodgkin’s lymphoma (NHL), in an attempt to assess the iron status of NHL patients.
Patients And Methods : the study was carried on 75 adult patients diagnosed as NHL at the National Cancer Institute, Cairo University.
Hematological studies and bone marrow (BM) aspirate examination for cellularity, siderob-lasts and marrow iron stores were done.
Iron metabolism investigations including serum iron, iron -binding capacity, % saturation, ferritin and transferrin receptors (sTfR) were carried out.
All the parameters were evaluated at different NHL phases of disease and compared in anemic and non-anemic patients.
Results : A significant increase in sTfR and BM iron stores was found in new and relapsing cases and in advanced stages of the disease, with normal levels in patients in remission.
The difference between anemic and non-anemic NHL patients was mainly in levels of serum ferri-tin and TfRs and in BM iron stores.
Conclusions: This study showed elevated sTfR levels in adult NHL patient's inspite of having abundant iron stores, and that its level reflected the activity and stage of the disease rather than iron status in this type of hemato-logical malignancy.
American Psychological Association (APA)
Hindawi, Dalia& Aql, Samiyah& al-Mahallawy, Haydar Ahmad& Abd al-latif, Nahlah A.& al-Attar, Inas. 2002. Serum transferrin receptor in relation to iron status in different disease stage of adult malignant lymphoma. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 3, pp.237-242.
https://search.emarefa.net/detail/BIM-67487
Modern Language Association (MLA)
Hindawi, Dalia…[et al.]. Serum transferrin receptor in relation to iron status in different disease stage of adult malignant lymphoma. Journal of the Egyptian National Cancer Institute Vol. 14, no. 3 (Sep. 2002), pp.237-242.
https://search.emarefa.net/detail/BIM-67487
American Medical Association (AMA)
Hindawi, Dalia& Aql, Samiyah& al-Mahallawy, Haydar Ahmad& Abd al-latif, Nahlah A.& al-Attar, Inas. Serum transferrin receptor in relation to iron status in different disease stage of adult malignant lymphoma. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 3, pp.237-242.
https://search.emarefa.net/detail/BIM-67487
Data Type
Journal Articles
Language
English
Notes
includes bibliographical references : pp. 241-242
Record ID
BIM-67487