Radiobiology of bladder urothelium clinical significance : an overview
Author
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 14, Issue 4 (31 Dec. 2002), pp.251-258, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2002-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Despite the fact that the bladder urothelium has a slow turnover rate, it can express a transient acute effect presenting as reduced bladder storage capacity.
This is thought to be due to radiation-induced functional and biochemical changes leading to increased bladder tone and is unrelated to cell proliferation.
Late radiation effect can be either (1) a consequential damage resulting from the biochemical intracellular changes of early damage, (b) primary late damage resulting from a late expression of urothelial cell death or stromal and vascular changes resulting from liberation of growth factors, principally the TGF-β.
For early effects the (α / β ratio is estimated to be range from 11-12 Gy as in a typical early reacting tissue while for late reactions an estimate of 5-6 Gy has been made suggesting less sensitivity to variations in the fraction size than most late reacting tissues.
Local instillation of formalin and hyperbaric oxygen provide useful therapeutic measures for late radiation bladder reactions.
American Psychological Association (APA)
Awwad, Hasan K.. 2002. Radiobiology of bladder urothelium clinical significance : an overview. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 4, pp.251-258.
https://search.emarefa.net/detail/BIM-67489
Modern Language Association (MLA)
Awwad, Hasan K.. Radiobiology of bladder urothelium clinical significance : an overview. Journal of the Egyptian National Cancer Institute Vol. 14, no. 4 (Dec. 2002), pp.251-258.
https://search.emarefa.net/detail/BIM-67489
American Medical Association (AMA)
Awwad, Hasan K.. Radiobiology of bladder urothelium clinical significance : an overview. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 4, pp.251-258.
https://search.emarefa.net/detail/BIM-67489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 257-258
Record ID
BIM-67489