Effects of cur cumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetyl cholinesterase in cadmium intoxicated mice
Author
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 2 (31 Mar. 2016), pp.219-228, 10 p.
Publisher
Publication Date
2016-03-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Abstract EN
Cadmium (Cd) exposure can induce acute lethal health-related threats in humans since it has an exceptional ability to accumulate in living organism tissues and cause toxicological effects.
Curcumin (Cur) on the other hand has a wide variety of biological activities and several studies have suggested its potential therapeutic or protective effects against several ailments and infections.
To study the effect of Cur on the toxicity of Cd, Swiss–Webster strain male and female mice (sixty each) were divided into 6 groups of ten each at random.
Group-1 served as the naı¨ve control and received no treatment.
Group-2, 3 and 4 were the experimental controls and were administered once a day with a single oral dose of 50% dimethyl sulfoxide (DMSO), Cur (300 mg/kg) or Cd (100 mg/kg) respectively, for 2 weeks.
Group-5 and 6 received Cur and Cd in combination once a day orally for 2 weeks except that Cur in a dose of 150 and 300 mg/kg to group 5 and 6 respectively, was administered one hour before Cd administration to both groups.
After treatment period, the male animals were subjected to social standard opponent test and females were subjected to the tube restraint tests and thereafter, their blood was collected to measure the blood composition indices and level of reproductive hormones.
The animals were sacrificed to collect their brain for the estimation of acetylcholinesterase (AChE).
Results indicated that Cd significantly increased nonsocial activities in males and latency to first bite in females, whereas the social activities in males and the number of bites in females were significantly decreased.
All measured indices of blood composition and levels of progesterone (female) and testosterone (male) in blood and AChE in their brain tissues were significantly decreased due to Cd treatment.
American Psychological Association (APA)
Abu al-Tawil, Qasim Muhammad. 2016. Effects of cur cumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetyl cholinesterase in cadmium intoxicated mice. Saudi Journal of Biological Sciences،Vol. 23, no. 2, pp.219-228.
https://search.emarefa.net/detail/BIM-674979
Modern Language Association (MLA)
Abu al-Tawil, Qasim Muhammad. Effects of cur cumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetyl cholinesterase in cadmium intoxicated mice. Saudi Journal of Biological Sciences Vol. 23, no. 2 (2016), pp.219-228.
https://search.emarefa.net/detail/BIM-674979
American Medical Association (AMA)
Abu al-Tawil, Qasim Muhammad. Effects of cur cumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetyl cholinesterase in cadmium intoxicated mice. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 2, pp.219-228.
https://search.emarefa.net/detail/BIM-674979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 226-228
Record ID
BIM-674979