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Outcome of patients with multiple myeloma and renal failure on novel regimens
Joint Authors
Sulaymani, Adil
Musawi, Asad Allah
Mujtahydi, Kourosh
Hamid, Gholamreza
Suliymanian, Tibah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 2 (30 Apr. 2016), pp.335-340, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-04-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Renal involvement occurs in 20–40 % of newly diagnosed multiple myeloma (MM) patients, and diagnosis of myeloma is frequently made after investigation for unexplained renal disease.
This is a retrospective study between 2006 and 2013 in which 57 consecutive patients seen at the Nephrology Unit with diagnosis of MM were enrolled.
MM was diagnosed for the first time because of renal dysfunction and/or proteinuria in these patients.
The mean age of the patients (65 % male) was 58.3 ± 12.7 years.
The median baseline serum creatinine was 3.5 mg/dL (1.4–14.5).
Anemia (hemoglobin <12 g / dL) was noted in 88 % and hypercalcemia (calcium > 10.5 mg/dL) in 35% of patients.
Early hemodialysis was started in 28 patients (49 %).
Thalidomide plus dexamethasone (16 % on bortezomib) were the main therapeutic regimens.
Three patients (5 %) underwent autologous stem cell transplantation.
Twenty-six patients (45.6 %) died during a median follow-up of 25 months (1–90).
The mean age of patients who died was significantly higher than the age in patients who were alive (62.2 ± 12.7 vs.
55.2 ± 11.9 years, respectively ; P = 0.037).
Early hemodialysis had no significant effect on mortality rate.
The one-, three- and fiveyear patient survival was 71%, 54 %, and 41%, respectively.
The median overall survival of patients was 50 months.
Prolonged patient survival can be expected in myeloma patients with renal failure or on dialysis by applying novel therapeutic agents.
American Psychological Association (APA)
Suliymanian, Tibah& Sulaymani, Adil& Musawi, Asad Allah& Mujtahydi, Kourosh& Hamid, Gholamreza. 2016. Outcome of patients with multiple myeloma and renal failure on novel regimens. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 2, pp.335-340.
https://search.emarefa.net/detail/BIM-678037
Modern Language Association (MLA)
Suliymanian, Tibah…[et al.]. Outcome of patients with multiple myeloma and renal failure on novel regimens. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 2 (Mar. / Apr. 2016), pp.335-340.
https://search.emarefa.net/detail/BIM-678037
American Medical Association (AMA)
Suliymanian, Tibah& Sulaymani, Adil& Musawi, Asad Allah& Mujtahydi, Kourosh& Hamid, Gholamreza. Outcome of patients with multiple myeloma and renal failure on novel regimens. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 2, pp.335-340.
https://search.emarefa.net/detail/BIM-678037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 339-340
Record ID
BIM-678037