Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft

Abstract EN

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described.

A 55-year-old male presented with rapid deterioration of renal function.

Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG.

He subsequently underwent renal transplant.

Two months later, he developed acute graft dysfunction.

Renal biopsy showed a recurrence of the disease.

Work up for multiple myeloma was positive.

Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.