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Pregabalin versus bromazepam as a sedative in embryo transfer during in-vitro fertilization
Joint Authors
al-Fawi, Dalya M.
Abu Sayf, Iman M. Kamal
Gerges, Niven
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 9, Issue 1 (31 Mar. 2016), pp.116-121, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
The majority of infertile women are young and healthy but exhibit stress, anxiety, and other psychological disorders associated with infertility.
This anxiety should be attenuated with appropriate drugs during premedication.
Moreover, after the procedure, patients report visceral pain resulting from cervical manipulation, which should be relieved with appropriate analgesia.
Objectives The aim of this study was to evaluate and compare the clinical effi cacy of oral premedication with pregabalin and bromazepam for sedation in terms of effectiveness and postoperative analgesia in patients undergoing embryo transfer during in-vitro fertilization (IVF).
Patients and methods A total of 60 healthy infertile consented female patients younger than 39 years with ASA physical status I or II who were scheduled for embryo transfer during IVF were randomized to receive either pregabalin (300 mg) (group A), bromazepam (3 mg) (group B), or placebo (folic acid 0.5 mg) (group C) 90 min before surgery as oral premedication.
The Ramsay sedation scale was used to evaluate preoperative sedation.
Hemodynamic data were recorded before premedication, just after induction, after recovery, and 2 and 4 h postoperatively.
Severity of postoperative pain was assessed using a visual analogue scale ( VAS).
Results Perioperative sedation levels were lighter in the pregabalin group than in the bromazepam group, as there were statistically signifi cant differences in terms of attenuation in mean arterial blood pressure and heart rate.
Moreover, VAS score was signifi cantly lower in the pregabalin group at induction, recovery, and 2 and 4 h after surgery.
Conclusion This study showed that the use of pregabalin 300 mg or bromazepam 3 mg causes good preoperative sedation with hemodynamic stability intraoperatively together with decreasing postoperative pain in embryo transfer during IVF procedure
American Psychological Association (APA)
Abu Sayf, Iman M. Kamal& al-Fawi, Dalya M.& Gerges, Niven. 2016. Pregabalin versus bromazepam as a sedative in embryo transfer during in-vitro fertilization. Ain Shams Journal of Anesthesiology،Vol. 9, no. 1, pp.116-121.
https://search.emarefa.net/detail/BIM-679070
Modern Language Association (MLA)
Abu Sayf, Iman M. Kamal…[et al.]. Pregabalin versus bromazepam as a sedative in embryo transfer during in-vitro fertilization. Ain Shams Journal of Anesthesiology Vol. 9, no. 1 (Jan. / Mar. 2016), pp.116-121.
https://search.emarefa.net/detail/BIM-679070
American Medical Association (AMA)
Abu Sayf, Iman M. Kamal& al-Fawi, Dalya M.& Gerges, Niven. Pregabalin versus bromazepam as a sedative in embryo transfer during in-vitro fertilization. Ain Shams Journal of Anesthesiology. 2016. Vol. 9, no. 1, pp.116-121.
https://search.emarefa.net/detail/BIM-679070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121
Record ID
BIM-679070