New schiff base derived from folic acid and 3-aminoacetophenone and its metal complexes with some transition metals and evaluation of their biological activity
Other Title(s)
تحضير و تشخيص قاعدة شف جديدة مشتقة من حامض الفوليك و (3-امينو اسيتوفينون) و معقداتها المختلطة مع بعض الفلزات الانتقالية و دراسة فاعليتها البايولوجية
Joint Authors
al-Salihi, Iman Ibrahim Abd al-Karim
al-Husayni, Ahmad Thabit Numan Husayn
Husayn, Khalid Fahd Ali
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 28, Issue 3 (31 Dec. 2015), pp.42-60, 19 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
19
Main Subjects
Topics
Abstract EN
The ligand [Potassium (E)-(4-(((2-((1-(3-aminophenyl) ethylidene) amino)-4-oxo-1,4- dihydropteridin-6-yl) methyl) amino)benzoyl)-L-glutamate] was prepared from the condensation reaction of folic acid with (3-aminoacetophenone) through Schiff reaction to give a new Schiff base ligand [H2L].
The ligand [H2L] was characterized by elemental analysis CHN, atomic absorption (A.A), (FT-I.R.), (U.V.-Vis), TLC, E.S.
mass (for spectroscopes), molar conductance, and melting point.
The new Schiff base ligand [H2L], reacts with Mn(II), Co(II), Ni(II), Cu(II), Cr(III) and Cd(II) metal ions and (2-aminophenol), (metal : derivative ligand : 2-aminophenol) to give a series of new mixed complexes in the general formula:- K3[M2(HL)(HA)2], (where M=Mn(II) and Cd(II)); K3[M2(HL)(HA)2.H2O], (where M= Cu(II) , Ni(II) and Co(II); and K[Cr2(HL)(HA)2(H2O)3].
These complexes were characterized by elemental analyses [(C.H.N) and (A.A)], (FT-I.R), (U.V-Vis.), molar conductance, 1H,13CNMR, biological activity, TLC and magnetic moment measurements.
From the above data the proposed molecular structure for Mn(II), Co(II), Ni(II), Cu(II), Cr(III) and Cd(II) complexes adopt a tetrahedral structure about the metal ions.
American Psychological Association (APA)
al-Husayni, Ahmad Thabit Numan Husayn& Husayn, Khalid Fahd Ali& al-Salihi, Iman Ibrahim Abd al-Karim. 2015. New schiff base derived from folic acid and 3-aminoacetophenone and its metal complexes with some transition metals and evaluation of their biological activity. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 28, no. 3, pp.42-60.
https://search.emarefa.net/detail/BIM-679099
Modern Language Association (MLA)
al-Husayni, Ahmad Thabit Numan Husayn…[et al.]. New schiff base derived from folic acid and 3-aminoacetophenone and its metal complexes with some transition metals and evaluation of their biological activity. Ibn al-Haitham Journal for Pure and Applied Science Vol. 28, no. 3 (2015), pp.42-60.
https://search.emarefa.net/detail/BIM-679099
American Medical Association (AMA)
al-Husayni, Ahmad Thabit Numan Husayn& Husayn, Khalid Fahd Ali& al-Salihi, Iman Ibrahim Abd al-Karim. New schiff base derived from folic acid and 3-aminoacetophenone and its metal complexes with some transition metals and evaluation of their biological activity. Ibn al-Haitham Journal for Pure and Applied Science. 2015. Vol. 28, no. 3, pp.42-60.
https://search.emarefa.net/detail/BIM-679099
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 50-59
Record ID
BIM-679099