Uni and multivariate optimization for the spectrophotometric determination of cimetidine drug via charge-transfer complex formation
Other Title(s)
إيجاد الظروف الفضلى بدراسة المتغيرات الأحادية و المتعددة لتقدير دواء السميتيدين بتكوين معقد الازدواج الأيوني
Joint Authors
al-Ghazzali, Ala Karim Muhammad
Dikran, Sarmad Bahjat
al-Jumayli, Ali Khalil Mahmud
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 28, Issue 3 (31 Dec. 2015), pp.113-128, 16 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Topics
Abstract EN
Charge transfer complex formation method has been applied for the spectrophotometric determination of cimetidine, in bulk sample and dosage form.
The method was accurate, simple, rapid, inexpensive and sensitive depending on the formed charge- transfer complex between cited drug and, 2,3-Dichloro-5,6-dicyano-p- benzoquinone (DDQ) as a chromogenic reagent.
The formed complex shows absorbance maxima at 587 nm against reagent blank.
The calibration graph is linear in the ranges of (5.0 - 50.0) μg.mL-1 with detection limit of 0.268μg.mL-1.
The results show the absence of interferences from the excipients on the determination of the drug.
Therefore the proposed method has been successfully applied for the determination of cimetidine in pharmaceutical preparations.
American Psychological Association (APA)
Dikran, Sarmad Bahjat& al-Ghazzali, Ala Karim Muhammad& al-Jumayli, Ali Khalil Mahmud. 2015. Uni and multivariate optimization for the spectrophotometric determination of cimetidine drug via charge-transfer complex formation. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 28, no. 3, pp.113-128.
https://search.emarefa.net/detail/BIM-679125
Modern Language Association (MLA)
Dikran, Sarmad Bahjat…[et al.]. Uni and multivariate optimization for the spectrophotometric determination of cimetidine drug via charge-transfer complex formation. Ibn al-Haitham Journal for Pure and Applied Science Vol. 28, no. 3 (2015), pp.113-128.
https://search.emarefa.net/detail/BIM-679125
American Medical Association (AMA)
Dikran, Sarmad Bahjat& al-Ghazzali, Ala Karim Muhammad& al-Jumayli, Ali Khalil Mahmud. Uni and multivariate optimization for the spectrophotometric determination of cimetidine drug via charge-transfer complex formation. Ibn al-Haitham Journal for Pure and Applied Science. 2015. Vol. 28, no. 3, pp.113-128.
https://search.emarefa.net/detail/BIM-679125
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 121-127
Record ID
BIM-679125