Spectrophotometric determination of amoxicillin trihydrate in pure and pharmaceutical dosage forms
Other Title(s)
التقدير الطيفي للأموكسيلين ثلاثي الماء في صورته النقية و المستحضر الصيدلاني
Joint Authors
Qadir, Hemin Abdul
Fakhri, Nabil Adil
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 28, Issue 3 (31 Dec. 2015), pp.142-153, 12 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract EN
A rapid and sensitive method for the determination of amoxicillin trihydrate (AMXT) based on the diazo-coupling reaction was studied.
Sulphanilic acid diazotizes with nitrite ion in acidic medium to produce a water soluble, colorless diazonium ion, which subsequently coupled with AMXT to form a colored azo dye in the alkaline medium, having maximum absorption at 455 nm.
The calibration graph showed that Beer's law is obeyed over the concentration range of 0.3 – 30.0 μg/mL of AMXT, with the detection limit of 0.15 μg/mL and molar absorptivity was 2.3 × 104 L/mol.cm.
The accuracy and the precision were acceptable depending upon the values of error percentage and relative standard deviation.
The influence of common interferences was studied and the method was applied with good recovery for the determination of AMXT in pure form and different pharmaceutical formulations, which commercially available in Erbil market.
American Psychological Association (APA)
Qadir, Hemin Abdul& Fakhri, Nabil Adil. 2015. Spectrophotometric determination of amoxicillin trihydrate in pure and pharmaceutical dosage forms. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 28, no. 3, pp.142-153.
https://search.emarefa.net/detail/BIM-679129
Modern Language Association (MLA)
Qadir, Hemin Abdul& Fakhri, Nabil Adil. Spectrophotometric determination of amoxicillin trihydrate in pure and pharmaceutical dosage forms. Ibn al-Haitham Journal for Pure and Applied Science Vol. 28, no. 3 (2015), pp.142-153.
https://search.emarefa.net/detail/BIM-679129
American Medical Association (AMA)
Qadir, Hemin Abdul& Fakhri, Nabil Adil. Spectrophotometric determination of amoxicillin trihydrate in pure and pharmaceutical dosage forms. Ibn al-Haitham Journal for Pure and Applied Science. 2015. Vol. 28, no. 3, pp.142-153.
https://search.emarefa.net/detail/BIM-679129
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 148-152
Record ID
BIM-679129