Synthesis, structural and biological efficiency studies of new Azo ligands and their complxes with Zn (II)‎, Cd(II)‎ and Hg (II)‎ metal ion

Abstract EN

The formation of Zn(II), Cd(II) and Hg(II) complexes was studied with two new hetrocyclic azo ligands 2-[4-(1-sulfonaphthalene)azo]-L-Histidine (L1) and 2-[7-(1-hydroxy- 3-sulfonaphthalene)azo]-L-Histidine (L2) derived from coupling reaction of diazonium salt of naphthionic acid and 7-amino-1-naphthol-5-sulfonic acid with L-Histidine in an alkaline ethanolic solution.

The structural features of all new compounds have been characterized from their elemental analyses, metal content, magnetic moment measurement, molar conductance & FT-IR, UV-Vis.

and 1HNMR spectral studies.

Furthermore,the composition of complexes have been studied following the mole ratio method after fixing the optimum condition (pH and concentration).Beer’s law was obeyed over a concentration range (610-5 - 810-5M).

All data showed that the complexes with (1:2) (M:L) metal to ligand, may be formulated as [M(L)2Cl2] and octahedral geometry, in which the ligands (L1 and L2) act as N,N-bidentate chelating agents, coordinated through the azo nitrogen near naphthyl moiety and heterocyclic nitrogen in L-Histidine.

The stability constant () and Gibbs free energy (G) of the complexes have also been studied.

Biological efficiency of ligands and their complexes were tested aginst Eschericha coli and Staphylococcus aureus.