Endotoxin enhancement of morphine-induced conditioned place preference
Joint Authors
Mao, Xin
Chang, Sulie L.
Sarkar, Sraboni
Vigorito, Michael
Source
Journal of Drug and Alcohol Research
Issue
Vol. 5, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Morphine, used clinically for pain management for its potent analgesic effects, has a high abuse potential.
In this study, we utilized the conditioned place preference (CPP) paradigm and tail-flick latency to examine the effects of the endotoxin lipopolysaccharide (LPS) on sensitivity to morphine.
Rats were pretreated with either LPS (250 μg / kg) or saline, followed by either a higher dose of LPS (2 mg / kg) or saline.
Rats were then given either morphine (3.5 mg / kg) or saline every other day for 6 d starting 72 h after the last dose of LPS or saline as part of the conditioning phase.
Drug preference was assessed during the postconditioning phase.
LPS-treated rats displayed a stronger and prolonged morphine preference during the 20 d of extinction testing.
A parallel analysis revealed that tail-flick latencies were significantly longer in LPS-treated rats.
Together, our data indicate that systemic infections can increase sensitivity to morphine both physiologically and behaviorally
American Psychological Association (APA)
Chang, Sulie L.& Sarkar, Sraboni& Vigorito, Michael& Mao, Xin. 2016. Endotoxin enhancement of morphine-induced conditioned place preference. Journal of Drug and Alcohol Research،Vol. 5, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-679435
Modern Language Association (MLA)
Chang, Sulie L.…[et al.]. Endotoxin enhancement of morphine-induced conditioned place preference. Journal of Drug and Alcohol Research Vol. 5 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-679435
American Medical Association (AMA)
Chang, Sulie L.& Sarkar, Sraboni& Vigorito, Michael& Mao, Xin. Endotoxin enhancement of morphine-induced conditioned place preference. Journal of Drug and Alcohol Research. 2016. Vol. 5, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-679435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-679435