Potential molecular mechanisms on the role of the sigma-1 receptor in the action of cocaine and methamphetamine
Joint Authors
Source
Journal of Drug and Alcohol Research
Issue
Vol. 5, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Topics
Abstract EN
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum membrane protein that involves a wide range of physiological functions.
The Sig-1R has been shown to bind psychostimulants including cocaine and methamphetamine (METH) and thus has been implicated in the actions of those psychostimulants.
For example, it has been demonstrated that the Sig-1R antagonists mitigate certain behavioral and cellular effects of psychostimulants including hyperactivity and neurotoxicity.
Thus, the Sig-1R has become a potential therapeutic target of medication development against drug abuse that differs from traditional monoamine-related strategies.
In this review, we will focus on the molecular mechanisms of the Sig-1R and discuss in such a manner with a hope to further understand or unveil unexplored relations between the Sig-1R and the actions of cocaine andMETH, particularly in the context of cellular biological relevance
American Psychological Association (APA)
Yasui, Yuko& Su, Tsung Ping. 2016. Potential molecular mechanisms on the role of the sigma-1 receptor in the action of cocaine and methamphetamine. Journal of Drug and Alcohol Research،Vol. 5, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-679447
Modern Language Association (MLA)
Yasui, Yuko& Su, Tsung Ping. Potential molecular mechanisms on the role of the sigma-1 receptor in the action of cocaine and methamphetamine. Journal of Drug and Alcohol Research Vol. 5 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-679447
American Medical Association (AMA)
Yasui, Yuko& Su, Tsung Ping. Potential molecular mechanisms on the role of the sigma-1 receptor in the action of cocaine and methamphetamine. Journal of Drug and Alcohol Research. 2016. Vol. 5, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-679447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 11-15
Record ID
BIM-679447