Comparative study between halothane and isoflurane on hypoxic pulmonary vasoconstriction and its reflection on tissue oxygenation during one lung anesthesia

Abstract EN

Purpose : there is a high incidence of hypoxemia and hypercapnia during one lung anesthesia in patients undergoing pulmonary surgeries for lung cancer.

Many factors are claimed to affect oxygenation during one lung an aesthesia.

In our work, we studied the effect of halothane and isoflurane on hypoxic pulmonary vasoconstriction (HPV) as an important factor affecting tissue oxygenation during one lung ventilation (OLV).

Materials and methods: Forty patients are randomly divided into two equal groups A and B : Group A : Patients are going to receive halothane an aesthesia.

Group B: Patients are going to receive isoflurane an aesthesia.

The effect of halothane and is oflurane on HPV was studied on both groups as reflected by systemic, pulmonary hemodynamics and blood gases.

In spite of the fact that is oflurane is known to abolish the HPV by its vasodilator effect.

Results: No marked difference was noticed between both groups as regard tissue oxygenation.

So, both is oflu-rane and halothane can be used safely during OLV.