Tumor necrosis factors, interferons and matrix metalloproteinase-9 in sera of nonhodgkin's lymphoma patients

Abstract EN

Objective : in the present study, the serum levels of some cytokines and the matrix metalloproteinase-9 (MMP-9) were studied in an attempt to find suitable markers for early diagnosis of non- Hodgkin’s lymphoma (NHL) and to assess their role in differentiating between disseminated and no disseminated cases.

Materials and Methods : the present study was conducted on 60 patients with no disseminated NHL, 14 patients with disseminated NHL, in addition to 10 healthy controls.

Their sera were used to determine tumor necrosis factor-a (TNF-a), tumor necrosis factor-(3 (TNF-(3), interferon-a (IFN-a), interferon-y (IFN-y) and Matrix Metalloproteinase-9 (MMP-9) using the ELISA technique.

Results : the results showed that the serum level of TNF-a and IFN-a can be used to differentiate between the control group and the group of NHL patients.

However, they could not differentiate between no disseminated NHL (nd- NHL) and disseminated NHL (d- NHL).

On the other hand, the serum level of TNF-(3 can be used to differentiate between nd- NHL and d- NHL, but not between the control group and nd-NHL.

Each of IFN-y and MMP-9 were not useful in discrimination between the control group and the diseased ones.

Our data revealed no correlation between serum level of the parameters investigated and the gender of the patients.

Conclusion : the present results revealed that TNF-a and INF-a can be used as diagnostic tools for NHL.

On the other hand, TNF-(3 is useful in the differentiation between nd-NHL and d-NHL.