A comparative immunohistochemical expression of cyclin D1 in keratocystic odontogenic tumor, dentigerous and radicular cysts
Joint Authors
al-Amiri, Yasamin Hamid
al-Azzawi, Lihadh M.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 1 (31 Mar. 2016), pp.92-97, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Background: Odontogenic cysts include a group of osseodestructive lesions that frequently affect the jaws.
Those cysts could derive from odontogenic epithelium and occur in the tooth-bearing regions of the jaws.
The aims of this study were to evaluate the immunohistochemical expression of Cyclin D1 in Keratocystic Odontogenic Tumor, Dentigerous cyst and Radicular cyst in epithelium and connective tissue capsule.
Materials and Methods: In this study, thirty formalin fixed paraffin embedded tissue blocks of Odontogenic cysts and Tumor, consist of 14 Keratocystic Odontogenic Tumor, 8 dentigerous cysts and 8 radicular cysts were analyzed immunohistochemically for the presence of Cyclin D1 proteins.
Results: Strong to moderate expression of Cyclin D1 in epithelium was found in Keratocystic Odontogenic Tumor cases with positive cases percentage was (85.7%).
Statistical significant differences (P<0.001) observed when comparing the three lesions.
Immunoreactivity of Cyclin D1 in stroma of Keratocystic Odontogenic Tumor was higher than in dentigerous cysts and radicular cysts cases.
However, the difference was not statistically significant (P<0.067).
Conclusion: The results of this study propose that high expression rate of Cyclin D1 might be one of the reasons for aggressive behavior of Keratocystic Odontogenic Tumor and high recurrence rate.
American Psychological Association (APA)
al-Amiri, Yasamin Hamid& al-Azzawi, Lihadh M.. 2016. A comparative immunohistochemical expression of cyclin D1 in keratocystic odontogenic tumor, dentigerous and radicular cysts. Journal of Baghdad College of Dentistry،Vol. 28, no. 1, pp.92-97.
https://search.emarefa.net/detail/BIM-683396
Modern Language Association (MLA)
al-Amiri, Yasamin Hamid& al-Azzawi, Lihadh M.. A comparative immunohistochemical expression of cyclin D1 in keratocystic odontogenic tumor, dentigerous and radicular cysts. Journal of Baghdad College of Dentistry Vol. 28, no. 1 (Mar. 2016), pp.92-97.
https://search.emarefa.net/detail/BIM-683396
American Medical Association (AMA)
al-Amiri, Yasamin Hamid& al-Azzawi, Lihadh M.. A comparative immunohistochemical expression of cyclin D1 in keratocystic odontogenic tumor, dentigerous and radicular cysts. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 1, pp.92-97.
https://search.emarefa.net/detail/BIM-683396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 97
Record ID
BIM-683396