Is there an association between vitamin D level and inflammatory markers in Hemodialysis patients ? : a cross-sectional study

Abstract EN

Vitamin D deficiency is very prevalent among the patients with end-stage renal disease.

The etiology of this is multifactorial, including nutritional deficiency, insufficient exposure to sunlight, race, obesity and not the least, impaired Vitamin D synthesis and metabolism in chronic kidney disease patients.

We hypothesized that lower Vitamin D level will be associated with higher inflammatory burden and low immunological response to hepatitis B vaccination in hemodialysis (HD) population.

The study was carried out in March 2013 among 100 HD patients who were identified to be eligible for the study.

This was a cross-sectional study analyzing the relationship between Vitamin D level and inflammatory markers in HD patients.

A relationship between Vitamin D level and markers of mineral bone disorder was also analyzed.

We also analyzed the relationship between Vitamin D level and hemoglobin and erythropoietin dosage.

Hemoglobin, transferrin saturation, and erythropoietin dose were used to study the relationship between Vitamin D and markers of anemia.

Antibodies to hepatitis B surface antigen were measured to study the response between Vitamin D level and immune response to hepatitis B vaccine.

Vitamin D levels were significantly lower in females compared to males (P = 0.009) and diabetics compared to non-diabetics (P = 0.02).

No significant association was observed between Vitamin D levels with immune response to hepatitis B vaccine (P = 0.89), C-reactive protein (P = 0.19), serum albumin (P = 0.17), hemoglobin level (P = 0.18,) and erythropoietin requirement (P = 0.87), parathyroid hormone (PTH) levels (P = 0.57), calcium levels (P = 0.79) and phosphate level (P = 0.1).