Contribution of glomerular morphometry to the diagnosis of pediatric nephropathies
Joint Authors
Rocha, Laura Penna
Marini, Mariana Barreto
Ramalho, Fernando Silva
Reis, Marlene Antonia dos
Correa, Rosana Rosa Miranda
Machado, Juliana Reis
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 3 (30 Jun. 2016), pp.493-499, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Only a few studies describe histopathological changes in renal biopsies performed in pediatric patients.
This study was conducted to identify an association between morphometric data in renal biopsies and renal function of these patients.
Fifty-nine individuals with ages between 2 and 18 years old were selected, who were divided into six groups consisting of frequent nephropathies in children and adolescents and one control group.
Proteinuria, urea, and creatinine values of the patients were recorded.
Interactive image analysis software Leica QWin® was used for morphometric analysis of Bowman’s capsule, glomerular capillary tuft, and Bowman’s space area.
The mean glomerular tuft area was higher in the membranous glomerulopathy group than in the podocytopathy group (57,101 ± 25,094 vs.
27,420 c ± 6279 μm2; P <0.05).
The median of Bowman’s space area was higher in the control group than in the podocytopathy group and in the thin basement membrane/Alport syndrome group [12,210 (7676–26,945) vs.
5801 (3031–7852) μm2; P <0.01 and 12210 (7676–26,945) vs.
4183 (3797–7992) μm2; P <0.01, respectively].
There was a positive and significant correlation between Bowman’s capsule area and the levels of proteinuria, creatinine, and urea of the patients, as well as between the glomerular tuft area and the levels of proteinuria, creatinine, and urea in the patients, regardless of their nephropathy.
Glomerular morphometry may contribute to the diagnosis of some glomerulopathies and the association between glomerular morphometric parameters, and laboratory data may promote a better understanding of the prognosis of these patients.
American Psychological Association (APA)
Marini, Mariana Barreto& Rocha, Laura Penna& Machado, Juliana Reis& Ramalho, Fernando Silva& Reis, Marlene Antonia dos& Correa, Rosana Rosa Miranda. 2016. Contribution of glomerular morphometry to the diagnosis of pediatric nephropathies. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 3, pp.493-499.
https://search.emarefa.net/detail/BIM-683485
Modern Language Association (MLA)
Marini, Mariana Barreto…[et al.]. Contribution of glomerular morphometry to the diagnosis of pediatric nephropathies. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 3 (May. / Jun. 2016), pp.493-499.
https://search.emarefa.net/detail/BIM-683485
American Medical Association (AMA)
Marini, Mariana Barreto& Rocha, Laura Penna& Machado, Juliana Reis& Ramalho, Fernando Silva& Reis, Marlene Antonia dos& Correa, Rosana Rosa Miranda. Contribution of glomerular morphometry to the diagnosis of pediatric nephropathies. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 3, pp.493-499.
https://search.emarefa.net/detail/BIM-683485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 498-499
Record ID
BIM-683485