Healthcare-associated methicillin-resistant Staphylococcus aureus : clinical characteristics and antibiotic resistance profile with emphasis on macrolide-lincosamide-streptogramin B resistance
Other Title(s)
البكتيريا العنقودية الذهبية المقاومة للميثيسيلين المرتبطة بالرعلية الصحية : الخصائص السريرية و مقاومة المضادات الحيوية مع التركيز على مقاومة الماكروليد و اللينكوساميد-ستربتوغرامين B
Joint Authors
Kumari, Jyoti
Shenoy, Shalini M.
Baliga, Shrikala
Chakrapani, M.,
Bhat1, Gopalkrishna K.
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 16, Issue 2 (31 May. 2016), pp.175-181, 7 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2016-05-31
Country of Publication
Oman
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objectives : Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen worldwide and its multidrug resistance is a major concern.
This study aimed to determine the clinical characteristics and antibiotic susceptibility profile of healthcare-associated MRSA with emphasis on resistance to macrolide-lincosamide-streptogramin B (MLSB) phenotypes and vancomycin.
Methods : This cross-sectional study was carried out between February 2014 and February 2015 across four tertiary care hospitals in Mangalore, South India.
Healthcare-associated infections among 291 inpatients at these hospitals were identified according to the Centers for Disease Control and Prevention guidelines.
Clinical specimens were collected based on infection type.
S.
aureus and MRSA isolates were identified and antibiotic susceptibility tests performed using the Kirby-Bauer disk diffusion method.
The minimum inhibitory concentration of vancomycin was determined using the Agar dilution method and inducible clindamycin resistance was detected with a double-disk diffusion test (D-test).
Results : Out of 291 healthcare-associated S.
aureus cases, 88 were MRSA (30.2 %).
Of these, 54.6 % were skin and soft tissue infections.
All of the isolates were susceptible to teicoplanin and linezolid.
Four MRSA isolates exhibited intermediate resistance to vancomycin (4.6 %).
Of the MRSA strains, 10 (11.4 %) were constitutive MLSB phenotypes, 31 (35.2 %) were inducible MLSB phenotypes and 14 (15.9 %) were macrolide-streptogramin B phenotypes.
Conclusion: Healthcare-associated MRSA multidrug resistance was alarmingly high.
In routine antibiotic susceptibility testing, a D-test should always be performed if an isolate is resistant to erythromycin but susceptible to clindamycin.
Determination of the minimum inhibitory concentration of vancomycin is necessary when treating patients with MRSA infections
American Psychological Association (APA)
Kumari, Jyoti& Shenoy, Shalini M.& Baliga, Shrikala& Chakrapani, M.,& Bhat1, Gopalkrishna K.. 2016. Healthcare-associated methicillin-resistant Staphylococcus aureus : clinical characteristics and antibiotic resistance profile with emphasis on macrolide-lincosamide-streptogramin B resistance. Sultan Qaboos University Medical Journal،Vol. 16, no. 2, pp.175-181.
https://search.emarefa.net/detail/BIM-683745
Modern Language Association (MLA)
Kumari, Jyoti…[et al.]. Healthcare-associated methicillin-resistant Staphylococcus aureus : clinical characteristics and antibiotic resistance profile with emphasis on macrolide-lincosamide-streptogramin B resistance. Sultan Qaboos University Medical Journal Vol. 16, no. 2 (May. 2016), pp.175-181.
https://search.emarefa.net/detail/BIM-683745
American Medical Association (AMA)
Kumari, Jyoti& Shenoy, Shalini M.& Baliga, Shrikala& Chakrapani, M.,& Bhat1, Gopalkrishna K.. Healthcare-associated methicillin-resistant Staphylococcus aureus : clinical characteristics and antibiotic resistance profile with emphasis on macrolide-lincosamide-streptogramin B resistance. Sultan Qaboos University Medical Journal. 2016. Vol. 16, no. 2, pp.175-181.
https://search.emarefa.net/detail/BIM-683745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 180-181
Record ID
BIM-683745