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Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates : synthesis and pharmacological activity
Joint Authors
Thore, S. N.
Gupta, Sunil V.
Baheti, Kamalkishor G.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 3 (31 May. 2016), pp.259-264, 6 p.
Publisher
Publication Date
2016-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
A series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesized from condensation of various hydrazides 2a–j with ketene dithioacetal.
The synthesized compounds were screened for in vivo analgesic and anti-inflammatory activities using acetic acid writhing test in mice and carrageenan-induced paw edema test in rat, respectively.
Diclofenac sodium was used as a standard drug for comparison.
Compounds 3a, 3c and 3d exhibited significant analgesic and anti-inflammatory activities at a dose of 25 mg/kg and showed quite less ulcerogenic index in the range of 0.9–1.12 whereas diclofenac sodium showed 3.10.
American Psychological Association (APA)
Thore, S. N.& Gupta, Sunil V.& Baheti, Kamalkishor G.. 2016. Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates : synthesis and pharmacological activity. Journal of Saudi Chemical Society،Vol. 20, no. 3, pp.259-264.
https://search.emarefa.net/detail/BIM-683786
Modern Language Association (MLA)
Thore, S. N.…[et al.]. Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates : synthesis and pharmacological activity. Journal of Saudi Chemical Society Vol. 20, no. 3 (May. 2016), pp.259-264.
https://search.emarefa.net/detail/BIM-683786
American Medical Association (AMA)
Thore, S. N.& Gupta, Sunil V.& Baheti, Kamalkishor G.. Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates : synthesis and pharmacological activity. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 3, pp.259-264.
https://search.emarefa.net/detail/BIM-683786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 264
Record ID
BIM-683786