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Synthesis and antitumor evaluation of thiophene based azo dyes incorporating pyrazolone moiety
Joint Authors
Barghuth, Majid A.
Jawdah, Mustafa A.
Fakhr al-Din, Hadir
Girges, Margret M.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 2 (31 Mar. 2016), pp.151-157, 7 p.
Publisher
Publication Date
2016-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
A series of thiophene incorporating pyrazolone moieties 5a–f and 6a–c were synthesized via diazo coupling of diazonium salt of 3-substituted-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophenes 1a–c with 3-methyl-1H-pyrazol-5(4H)-one, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one or 3-amino- 1H-pyrazol-5(4H)-one, respectively.
Newly synthesized dyes were applied to polyester fabric as disperse dyes in which their color measurements and fastness properties were evaluated.
These dyes showed generally red to blue shifted color with high extinction coefficient in comparison with aniline- based azo dyes.
The antitumor activity of the synthesized dyes was evaluated.
The results showed clearly that most of them exhibited good activity and compounds 5c and 5d exhibited moderate activity.
American Psychological Association (APA)
Jawdah, Mustafa A.& Fakhr al-Din, Hadir& Girges, Margret M.& Barghuth, Majid A.. 2016. Synthesis and antitumor evaluation of thiophene based azo dyes incorporating pyrazolone moiety. Journal of Saudi Chemical Society،Vol. 20, no. 2, pp.151-157.
https://search.emarefa.net/detail/BIM-683793
Modern Language Association (MLA)
Girges, Margret M.…[et al.]. Synthesis and antitumor evaluation of thiophene based azo dyes incorporating pyrazolone moiety. Journal of Saudi Chemical Society Vol. 20, no. 2 (Mar. 2016), pp.151-157.
https://search.emarefa.net/detail/BIM-683793
American Medical Association (AMA)
Jawdah, Mustafa A.& Fakhr al-Din, Hadir& Girges, Margret M.& Barghuth, Majid A.. Synthesis and antitumor evaluation of thiophene based azo dyes incorporating pyrazolone moiety. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 2, pp.151-157.
https://search.emarefa.net/detail/BIM-683793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 156-157
Record ID
BIM-683793