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Synthesis, and characterization of a new series of sulfite and sulfate derivatives of D-mannitol
Joint Authors
al-Majid, Abd Allah M. A.
al-Ajami, Muhammad H. M.
Mabkhut, Yahya Nasir
Barakat, Asim
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 3 (31 May. 2016), pp.307-312, 6 p.
Publisher
Publication Date
2016-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
In this work, synthesis and characterization of a series of D-Mannitol derivatives with sulfite 2a–d and sulfate 3a–d moieties have been investigated.
The method entails a two-step synthesis.
The first step involves the Sharpless-type reaction of DIOL 1a–d with SOCl2 in CH2Cl2 in the presence of Et3N to afford the intermediate sulfite derivatives 2a–d in good yield.
The second step includes the oxidation reaction of the resulting intermediate in the presence of NaIO4 in a mixture of CCl4 / CH3CN/H2O (3 / 3 / 2 ratio) in the presence of catalytic amount of RuCl3ÆH2O to afford the desired sulfate moiety 3a–d in a moderate to high yield (66–96 %).
The structures of all newly synthesized compounds have been elucidated by 1H, 13C NMR, GCMS, and IR spectrometry.
American Psychological Association (APA)
al-Majid, Abd Allah M. A.& Barakat, Asim& Mabkhut, Yahya Nasir& al-Ajami, Muhammad H. M.. 2016. Synthesis, and characterization of a new series of sulfite and sulfate derivatives of D-mannitol. Journal of Saudi Chemical Society،Vol. 20, no. 3, pp.307-312.
https://search.emarefa.net/detail/BIM-683841
Modern Language Association (MLA)
al-Majid, Abd Allah M. A.…[et al.]. Synthesis, and characterization of a new series of sulfite and sulfate derivatives of D-mannitol. Journal of Saudi Chemical Society Vol. 20, no. 3 (May. 2016), pp.307-312.
https://search.emarefa.net/detail/BIM-683841
American Medical Association (AMA)
al-Majid, Abd Allah M. A.& Barakat, Asim& Mabkhut, Yahya Nasir& al-Ajami, Muhammad H. M.. Synthesis, and characterization of a new series of sulfite and sulfate derivatives of D-mannitol. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 3, pp.307-312.
https://search.emarefa.net/detail/BIM-683841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 312
Record ID
BIM-683841