Brønsted acidic ionic liquid catalyzed synthesis of poly-substituted hydroquinolines through diastereoselective, one-pot and pseudoeight-component reaction

Abstract EN

We have developed an efficient diastereoselective synthesis of poly-substituted hydroquinolines from commercially available starting materials, Meldrum’s acid, aromatic aldehydes and arylamines, in a simple and one-pot reaction using Brønsted acidic ionic liquid (4-sulfobutyl)- tris(4-sulfophenyl) phosphonium hydrogen sulfate.

These three materials react together through pseudo-eight-components reaction to generate complex products with four stereocenters that involves ten new bond formations.

This synthetic method can be a combination of Knoevenagel and Michael reactions.