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Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in Vitro
Joint Authors
Khan, Muhsin Ali
Ahmad, Rummanah
Srivastava, A. N.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 28, Issue 2 (30 Jun. 2016), pp.81-88, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aroma can have far reaching effects on mind, body and soul.
Pleasant aromas are known to have a soothing effect on the mind and are known to relieve stress and enhance concentration.
Recently, it has been demonstrated that aroma may also have some curative effects as well as benefits and can be used both for prophylaxis and therapy of diseases.
Our aim was to test our hypothesis whether aroma can cure or prevent cancer.
Methyl butyrate (MB) is the methyl ester of butyric acid having a characteristic sweet and fruity odor like that of apples and pineapples.
It occurs in many plant products in minute quantities and in pineapple oil.
Methods: In the present study, the effect of aroma of MB has been evaluated on human breast cancer cell line MDA-MB-231 in vitro.
The percentage viability of the cell line was determined by using Trypan blue dye exclusion assay.
Results: It was found that MB at a concentration of 0.01 M was effective in causing considerable cytotoxicity (40%) in breast cancer cells (without even coming in contact with cells) while at 0.02 M, % cytotoxicity was found to be 50%.
Mechanism of action of MB on cancer cells was investigated by acridine orange–ethidium bromide assay using fluorescence microscopy and DNA fragmentation assay.
MB aroma appeared to induce necrosis in cancer cells exposed to it.
Conclusion: No study involving the effect of aroma/smell on cancer cells has ever been reported before and warrants further investigation on other cancer and normal cell lines.
American Psychological Association (APA)
Khan, Muhsin Ali& Ahmad, Rummanah& Srivastava, A. N.. 2016. Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in Vitro. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 2, pp.81-88.
https://search.emarefa.net/detail/BIM-684055
Modern Language Association (MLA)
Khan, Muhsin Ali…[et al.]. Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in Vitro. Journal of the Egyptian National Cancer Institute Vol. 28, no. 2 (Jun. 2016), pp.81-88.
https://search.emarefa.net/detail/BIM-684055
American Medical Association (AMA)
Khan, Muhsin Ali& Ahmad, Rummanah& Srivastava, A. N.. Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in Vitro. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 2, pp.81-88.
https://search.emarefa.net/detail/BIM-684055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88
Record ID
BIM-684055