Altered fractionation radiotherapy in head and neck squamous cell carcinoma
Joint Authors
Benson, Rony
Mallick, Supriya
Julka, Pramod K.
Rath, Goura K.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 28, Issue 2 (30 Jun. 2016), pp.73-80, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction : Fractionation plays a pivotal role in determining the effectiveness of radiation and follows the principle of 4 ‘‘R” of radiobiology.
The various altered fractionation schedules used are hyper-fractionation, accelerated fractionation, and hypo fractionation.
Methods : We reviewed the landmark articles published in the peer reviewed journals to summarize the beneficial role of altered fractionation in the treatment of head and neck carcinoma.
Results : Hyper-fractionation definitely gives very good overall survival benefit for locally advanced head and neck patient’s equivalent to survival benefit to that of concurrent chemoradiotherapy.
Adding concomitant chemotherapy to altered fractionation is a logical approach to improve survival in locally advanced head and neck cancer patients, but it may be at a cost of higher toxicity.
Mild hypo fractionation may be beneficial in early laryngeal cancers and may help in achieving better local control.
Conclusion : Altered fractionation is a very important treatment schema and requires the reinforcement of its use.
American Psychological Association (APA)
Mallick, Supriya& Benson, Rony& Julka, Pramod K.& Rath, Goura K.. 2016. Altered fractionation radiotherapy in head and neck squamous cell carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 2, pp.73-80.
https://search.emarefa.net/detail/BIM-684076
Modern Language Association (MLA)
Mallick, Supriya…[et al.]. Altered fractionation radiotherapy in head and neck squamous cell carcinoma. Journal of the Egyptian National Cancer Institute Vol. 28, no. 2 (Jun. 2016), pp.73-80.
https://search.emarefa.net/detail/BIM-684076
American Medical Association (AMA)
Mallick, Supriya& Benson, Rony& Julka, Pramod K.& Rath, Goura K.. Altered fractionation radiotherapy in head and neck squamous cell carcinoma. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 2, pp.73-80.
https://search.emarefa.net/detail/BIM-684076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 79-80
Record ID
BIM-684076