Evaluate the cytokine IL-6 as an inflammatory indicator against isolated parasites in appendicitis patients

Abstract EN

Appendicitis is one of most common abdominal pains requiring emergency surgery, Acute appendicitis is acute condition happened as a result of obstruction from parasites present.

114 blood sample ware collected from patients who had undergone appendectomy operation at periods from 21-12- 2010 to 1-4-2011 in General Teaching Hilla Hospital.

This study is done to determine pathogenesis of parasites and determine the type of immune statue for appendicitis caused by parasites by estimating concentrations of IL-6 as an immune marker .

The rate of samples that gave positive for parasites isolate was 29.82% , while 70.14% parasitically negative , also the total number of isolated parasites was 7 genera.

The common isolated parasites were Entamebae histolotica 37.8% , Entrobius vermocalaris 35.1% , Schistosoma haematobium , Blantidium coli, Trichurus trichora,Giardia lamblia and Schistosoma mansoni in rate 5.4% for each one .

Immunological tests to sera of patients with appendicitis refer to significance increasing in the concentration of IL-6 for all patients at different age groups, compared to control and the highest concentration of them in the age group 40-49 years ( 5.944 ± 0.004 pg/ml) , the present study shows absence of parasite as causative for appendix infection in ≤10 age group , This study refers to the role of cellular immune response through appendix infection with different parasites.

incidence of appendicitis appear in both sex at same rate 50% .

Appendicitis appear in all age groups the age period 10-19 show highly infection rate with parasite.