Detection of galactomannan antigen in the serum of Iraqi patients with suspected invasive aspergillosis
Joint Authors
Ali, Rawaa
al-Wattar, Wifaq M. Ali
Jawad, Ali M.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 58, Issue 1 (31 Mar. 2016), pp.71-74, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : Aspergillosis is a large spectrum of diseases caused by members of the genus Aspergillus.
Invasive aspergillosis is a severe infection that occurs in patients with prolonged neutropenia, following chemotherapy,transplantation,or immunosuppressive protocols .Galactomannan ( GM) is a molecule ,found in the cell wall of Aspergillus species and is released in the blood during growth .The detection of GM in the blood is used to diagnose the invasive Aspergillosis in humans using ELISA assay.
Objectives : To detect Galactomannan antigen in in the serum of immunocompramized patients suspected to have invasive aspergillosis.
Patients and methods : This study was conducted on 50 patients from the hematology&oncology department,of Baghdad teaching hospital and pediatric oncology wards ,from March 2013 to October 2013.The patients presented with fever that is not responding to antibiotics along with cough and sputum and abnormal chest X-ray findings suspicious of IA.
11 healthy Iraqi individuals served as a control group.
Results : ELISA test was positive in 39 of 50 (78%)while all of the control group individuals were negative(100%).The concentration of galactomannan antigen detected by ELISA was statistically significant when compared to control group( OD 0.658±0.033 vs 0.191±0.020 respectively) ( p<0.05).
Conclusion : The detection of galactomannan antigen is a very useful and rapid method for the diagnosis of invasive aspergillosis disease in immunocompromised patients.
American Psychological Association (APA)
Ali, Rawaa& Jawad, Ali M.& al-Wattar, Wifaq M. Ali. 2016. Detection of galactomannan antigen in the serum of Iraqi patients with suspected invasive aspergillosis. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 1, pp.71-74.
https://search.emarefa.net/detail/BIM-685326
Modern Language Association (MLA)
Jawad, Ali M.…[et al.]. Detection of galactomannan antigen in the serum of Iraqi patients with suspected invasive aspergillosis. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 1 (2016), pp.71-74.
https://search.emarefa.net/detail/BIM-685326
American Medical Association (AMA)
Ali, Rawaa& Jawad, Ali M.& al-Wattar, Wifaq M. Ali. Detection of galactomannan antigen in the serum of Iraqi patients with suspected invasive aspergillosis. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 1, pp.71-74.
https://search.emarefa.net/detail/BIM-685326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 73-74
Record ID
BIM-685326