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Analysis of the acquisition of drug discrimination reveals differences between a high versus low training dose of ± 3, 4-methylenedioxymethamphetamine (MDMA)
Joint Authors
Webster, Jeremy
Harper, David P.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 5, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background.
Studies of the discriminative stimulus effects of the recreational drug, ±3,4-methylenedioxymethamphetamine (MDMA), typically use a dose of 1.5 mg/kg during training.
This dose is relatively low compared to those used in other behavioral paradigms.
Purpose.
The present study assessed the ability of this low dose of MDMA and a higher dose of 3.0 mg / kg to support drug-discrimination learning in rats.
Procedures.
Daily training sessions were preceded by an injection of either MDMA (1.5mg / kg or 3.0mg/kg) or saline.
Injections alternated in a pseudorandom fashion for a total of 63 sessions.
Criteria for the acquisition of the MDMA/saline discrimination were increased from 4 to 10 successive, and successful, discriminations.
As the acquisition criteria became more stringent, the impact on the low dose discrimination was greater than the impact on the high dose discrimination.
Conclusions.
These results suggest that the drug discrimination produced by 1.5mg/kg MDMA may be less reliable than when a higher dose is employed, especially when the number of training sessions is limited.
The data further suggest that 3.0mg/kg MDMA produced a robust discriminative stimulus effect which may be better suited to experiments of this nature
American Psychological Association (APA)
Webster, Jeremy& Harper, David P.. 2016. Analysis of the acquisition of drug discrimination reveals differences between a high versus low training dose of ± 3, 4-methylenedioxymethamphetamine (MDMA). Journal of Drug and Alcohol Research،Vol. 5, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-685410
Modern Language Association (MLA)
Webster, Jeremy& Harper, David P.. Analysis of the acquisition of drug discrimination reveals differences between a high versus low training dose of ± 3, 4-methylenedioxymethamphetamine (MDMA). Journal of Drug and Alcohol Research Vol. 5 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-685410
American Medical Association (AMA)
Webster, Jeremy& Harper, David P.. Analysis of the acquisition of drug discrimination reveals differences between a high versus low training dose of ± 3, 4-methylenedioxymethamphetamine (MDMA). Journal of Drug and Alcohol Research. 2016. Vol. 5, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-685410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-7
Record ID
BIM-685410