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Zoledronic acid and leuprorelin acetate, alone or in combination, similarly reduce proliferation and migration of prostate cancer cells in vitro
Joint Authors
Mognetti, Barbara
Montagna, Giuseppe La
Perrelli, Maria Giulia
Marino, Silvia
Pagliaro, Pasquale
Cracco, Cecilia M.
Penna, Claudia
Source
International Journal of Medical Biology
Issue
Vol. 1, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We studied the effects of zoledronic acid (ZA) and leuprorelin acetate (LA) separately and combined on a human cell line derived from a bone metastasis of prostatic adenocarcinoma (PC3).
In particular, we focused on the effects that drugs given singularly or in association may play on tumor evolution and metastatization.
Cell proliferation, 2D- and 3D-migration were studied in basal conditions and under attractive stimuli exerted by bone marrow mesenchymal stem cells (BM-MSC).
Either drug decreased PC3 proliferation, though ZA was much more cytotoxic than LA.
However, LA cytotoxic concentrations are higher than those usually reached in vivo.
Subtoxic concentration of either drug inhibited migration especially under BM-MSC medium stimuli via an Akt-dependent mechanism.
The capability of either drug to inhibit cellular migration is in line with their well-known effect in limiting metastatization.
Intriguingly, no additive effect on the antiproliferative activity or in hindering migration is observed when the drugs are administered concomitantly, compared to the effects of each drug alone.
American Psychological Association (APA)
Mognetti, Barbara& Montagna, Giuseppe La& Perrelli, Maria Giulia& Marino, Silvia& Pagliaro, Pasquale& Cracco, Cecilia M.…[et al.]. 2014. Zoledronic acid and leuprorelin acetate, alone or in combination, similarly reduce proliferation and migration of prostate cancer cells in vitro. International Journal of Medical Biology،Vol. 1, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-685566
Modern Language Association (MLA)
Mognetti, Barbara…[et al.]. Zoledronic acid and leuprorelin acetate, alone or in combination, similarly reduce proliferation and migration of prostate cancer cells in vitro. International Journal of Medical Biology Vol. 1 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-685566
American Medical Association (AMA)
Mognetti, Barbara& Montagna, Giuseppe La& Perrelli, Maria Giulia& Marino, Silvia& Pagliaro, Pasquale& Cracco, Cecilia M.…[et al.]. Zoledronic acid and leuprorelin acetate, alone or in combination, similarly reduce proliferation and migration of prostate cancer cells in vitro. International Journal of Medical Biology. 2014. Vol. 1, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-685566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-685566