Stressful events in early life lead to aberrant ghrelin and appetite regulation to stress in adulthood
Joint Authors
Yu, Jun
Cheung, Cynthia K. Y.
Lee, Ying Ying
Ng, Siew C.
Lam, Fung Chun
Law, Wai Tak
Sung, Joseph J. Y.
Chan, Francis K. L.
Wu, Justin C. Y.
Source
Neuroenterology : Journal of Neurology and Gut
Issue
Vol. 1, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Stressful events in early life predispose to the development of eating disorders in adulthood.
This study investigates how neonatal maternal separation (NMS) affects satiety and ghrelin secretion in adulthood.
Methods.
Sprague-Dawley rats underwent NMS and controls were without NMS.
Experiments were conducted on day 60: (1) water avoidance stress (WAS); (2) feeding after overnight fasting; (3) feeding after overnight fasting and WAS.
Blood samples, gastric and hypothalamic tissues expression were collected for ghrelin analysis.
Results.
(1) MS rats had a higher basal ghrelin.
After WAS, MS rats had enhanced ghrelin.
(2) A higher initial calorie intake and lower postprandial gastric ghrelin protein in MS are observed without difference in overall calorie intake.
(3) MS had symptoms of binge eating and early satiation.
Overall reduction of calorie intake was observed until 48 hours in MS.
Conclusion.
Stressful events in early life led to aberrant ghrelin profile and early satiation in response to stressful experience in adulthood.
American Psychological Association (APA)
Cheung, Cynthia K. Y.& Lee, Ying Ying& Ng, Siew C.& Lam, Fung Chun& Law, Wai Tak& Yu, Jun…[et al.]. 2012. Stressful events in early life lead to aberrant ghrelin and appetite regulation to stress in adulthood. Neuroenterology : Journal of Neurology and Gut،Vol. 1, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-685815
Modern Language Association (MLA)
Cheung, Cynthia K. Y.…[et al.]. Stressful events in early life lead to aberrant ghrelin and appetite regulation to stress in adulthood. Neuroenterology : Journal of Neurology and Gut Vol. 1 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-685815
American Medical Association (AMA)
Cheung, Cynthia K. Y.& Lee, Ying Ying& Ng, Siew C.& Lam, Fung Chun& Law, Wai Tak& Yu, Jun…[et al.]. Stressful events in early life lead to aberrant ghrelin and appetite regulation to stress in adulthood. Neuroenterology : Journal of Neurology and Gut. 2012. Vol. 1, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-685815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-685815