Differential protein expression in the nucleus accumbens and amygdala of Lewis and Fischer 344 rats, and its relevance in drug addiction
Source
Journal of Drug and Alcohol Research
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
English Abstract
The Lewis (LEW) and Fischer 344 (F344) rat strains are widely used as models of genetic vulnerability to drug addiction, particularly since these two strains show different patterns of drug selfadministration.
We previously performed an unbiased and genomewide microarray analysis to define the differences in gene expression in the nucleus accumbens (NAcc) and prefrontal cortex between LEW and F344 rats.
In this study, we set out to determine the strain differences in the NAcc and amygdala at the protein level using bidimensional gel electrophoresis.
As such, 11 proteins were found to be differentially expressed between these two strains, the activity of which was mainly related to vesicular trafficking (STXBP1 and GDI1), energy metabolism (ATP5B, ENO2, and ACOT7), and cytoskeletal formation.
This information might be useful to search for new molecular targets to screen individuals at high risk of developing an addictive disorder
Data Type
Conference Papers
Record ID
BIM-685861
American Psychological Association (APA)
Roura Mart´ınez, David& Ucha, Marcos& Coria, Santiago M.& Higuera Matas, Alejandro& Ambrosio, Emilio. 2014-12-31. Differential protein expression in the nucleus accumbens and amygdala of Lewis and Fischer 344 rats, and its relevance in drug addiction. International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico). . Vol. 3 (2014), pp.1-8.Cairo Egypt : Ashdin Publishing Corporation.
https://search.emarefa.net/detail/BIM-685861
Modern Language Association (MLA)
Roura Mart´ınez, David…[et al.]. Differential protein expression in the nucleus accumbens and amygdala of Lewis and Fischer 344 rats, and its relevance in drug addiction. . Cairo Egypt : Ashdin Publishing Corporation. 2014-12-31.
https://search.emarefa.net/detail/BIM-685861
American Medical Association (AMA)
Roura Mart´ınez, David& Ucha, Marcos& Coria, Santiago M.& Higuera Matas, Alejandro& Ambrosio, Emilio. Differential protein expression in the nucleus accumbens and amygdala of Lewis and Fischer 344 rats, and its relevance in drug addiction. . International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico).
https://search.emarefa.net/detail/BIM-685861