Hotdogs and beer : dietary nitrosamine exposure exacerbates neurodevelopmental effects of ethanol in fetal alcohol spectrum disorder
Joint Authors
Tong, Ming
Andreani, Tomas
De La Monte, Suzanne M.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 3, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the immature brain, ethanol impairs insulin, insulin-like growth factor (IGF) and other trophic factor signaling, increases cellular stress, and impairs neuronal and glial functions.
However, given the phenotypic heterogeneity of fetal alcohol spectrum disorder (FASD), which is not always ethanol dose-dependent, we hypothesized that cofactors modulate spectrum and severity of disease.
Herein, we determined if N-nitrosodiethylamine (NDEA) exposures could mimic or exacerbate ethanol’s effects on cerebellar development; NDEA is present in processed foods, inhibits insulin signaling, and promotes oxidative injury.
Rat pups were binge ethanol (2 g/kg) or vehicle exposed on postnatal day 3 (P3), P5, P7, and P9; and treated with vehicle or NDEA (2mg/kg) on P7.
Ethanol and NDEA disrupted cerebellar foliation and white matter integrity, inhibited expression of oligodendrocyte and astrocyte proteins, and increased expression of ER stress genes.
Combined exposures had qualitatively additive effects.
Therefore, cofactor exposures can either mimic or influence the phenotypic features of FASD
American Psychological Association (APA)
Andreani, Tomas& Tong, Ming& De La Monte, Suzanne M.. 2014. Hotdogs and beer : dietary nitrosamine exposure exacerbates neurodevelopmental effects of ethanol in fetal alcohol spectrum disorder. Journal of Drug and Alcohol Research،Vol. 3, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-685874
Modern Language Association (MLA)
Andreani, Tomas…[et al.]. Hotdogs and beer : dietary nitrosamine exposure exacerbates neurodevelopmental effects of ethanol in fetal alcohol spectrum disorder. Journal of Drug and Alcohol Research Vol. 3 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-685874
American Medical Association (AMA)
Andreani, Tomas& Tong, Ming& De La Monte, Suzanne M.. Hotdogs and beer : dietary nitrosamine exposure exacerbates neurodevelopmental effects of ethanol in fetal alcohol spectrum disorder. Journal of Drug and Alcohol Research. 2014. Vol. 3, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-685874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-685874