Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor
Joint Authors
Shelton, Keith L.
Nicholson, Katherine L.
Source
Journal of Drug and Alcohol Research
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
English Abstract
Inhalants are distinguished as a class primarily based upon a shared route of administration.
Grouping inhalants according to their abuse-related in vivo pharmacological effects using the drug discrimination procedure has the potential to provide a more relevant classification scheme to the research and treatment community.
Mice were trained to differentiate the introceptive effects of the trichloroethylene vapor from air using an operant procedure.
Trichloroethylene is a chlorinated hydrocarbon solvent once used as an anesthetic as well as in glues and other consumer products.
It is now primarily employed as a metal degreaser.
We found that the stimulus effects of trichloroethylene were similar to those of other chlorinated hydrocarbon vapors, the aromatic hydrocarbon toluene and the vapor anesthetics methoxyflurane and isoflurane.
The stimulus effects of trichloroethylene overlapped with those of the barbiturate methohexital, to a lesser extent the benzodiazepine midazolam and ethanol.
N-methyl-D-aspartate (NMDA) antagonists, the kappa-opioid agonist U50,488, and the mixed 5-HT agonist 1-(3-chlorophenyl)piperazine (mCPP) largely failed to substitute for trichloroethylene.
These data suggest that stimulus effects of chlorinated hydrocarbon vapors are mediated at least partially by GABAA receptor positive modulatory effects.
Data Type
Conference Papers
Record ID
BIM-685892
American Psychological Association (APA)
Shelton, Keith L.& Nicholson, Katherine L.. 2014-12-31. Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor. International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico). . Vol. 3 (2014), pp.1-10.Cairo Egypt : Ashdin Publishing Corporation.
https://search.emarefa.net/detail/BIM-685892
Modern Language Association (MLA)
Shelton, Keith L.& Nicholson, Katherine L.. Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor. . Cairo Egypt : Ashdin Publishing Corporation. 2014-12-31.
https://search.emarefa.net/detail/BIM-685892
American Medical Association (AMA)
Shelton, Keith L.& Nicholson, Katherine L.. Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor. . International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico).
https://search.emarefa.net/detail/BIM-685892