Modeling disease evolution with multilevel selection : HIV as a quasispecies social genome
Joint Authors
Kapheim, Karen M.
Nonacs, Peter
Source
Journal of Evolutionary Medicine
Issue
Vol. 1, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
How genetically simple pathogens like HIV overwhelm complex immune systems is not fully understood.
One unexplored possibility is that epistatic interactions across genetically complementary quasispecies (i.e., grouplevel social heterosis) allow pathogens to escape immune suppression.
We tested this hypothesis by simulating an “HIV-like” pathogen under simultaneous individual- and group-level selection.
Results matched in vivo HIV infection patterns, with virulence correlating to intrahost viral diversity patterns, variable times to immune system collapse extrinsic to variation in host immunity, unchanging virulence across infections, repeated evolution of complementary quasispecies clades, and numerous reversion mutations after virus transmission.
Thus when group selection drives pathogen evolution, studying individual clones or consensus sequences will miss the possible effects of genetically synergistic “social genomes” on virulence.
Furthermore, results suggest that virulence is reducible by manipulating selection to favor individual-level competitive ability in viruses.
Overall, social genome models of pathogen interaction could produce novel approaches in studying diseases.
American Psychological Association (APA)
Nonacs, Peter& Kapheim, Karen M.. 2013. Modeling disease evolution with multilevel selection : HIV as a quasispecies social genome. Journal of Evolutionary Medicine،Vol. 1, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-685905
Modern Language Association (MLA)
Nonacs, Peter& Kapheim, Karen M.. Modeling disease evolution with multilevel selection : HIV as a quasispecies social genome. Journal of Evolutionary Medicine Vol. 1 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-685905
American Medical Association (AMA)
Nonacs, Peter& Kapheim, Karen M.. Modeling disease evolution with multilevel selection : HIV as a quasispecies social genome. Journal of Evolutionary Medicine. 2013. Vol. 1, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-685905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-13
Record ID
BIM-685905