Mycosis fungoides and head and neck malignancies

Abstract EN

Mycosis fungoides is a cutaneous T-cell lymphoma characterized by cutaneous patches and plaques that may progress to hematologic involvement and Sezary syndrome.

Second primary tumors have been described in the literature without emphasis on head and neck neoplasms.

We report two cases of head and neck malignancies in patients with a history of mycosis fungoides.

A PubMed literature search was performed and results were reviewed.

Second primary tumors in the head and neck have been reported in the nose and nasal cavity, sinuses, oral cavity, pharynx, hypopharynx, larynx, tracheobronchial tree, thymus, and skin.

We present cases of submandibular mucoepidermoid carcinoma and papillary thyroid carcinoma in patients with a history of mycosis fungoides.

Mycosis fungoides may confer increased risk of developing a second primary neoplasm of the head and neck.

Possible mechanisms may includeimmunosuppression inherent in treatment modalities, the disease course of mycosis fungoides, or related genetic mutations.