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Immune characterization of wild-caught rattus norvegicus suggests diversity of immune activity in biome-normal environments
Joint Authors
Perkins, Sarah E.
Parker, William
Lin, Shu S.
Holzknecht, Zoie E.
Trama, Ashley M.
Everett, Mary Lou
Thomas, Anitra D.
Su, Kuei-Ying
Lee, Sean M.
Whitesides, John F.
McDermott, Patrice
Source
Journal of Evolutionary Medicine
Issue
Vol. 1, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Biome depletion, or loss of co-evolved constituents within the ecosystem of the human body, has become the leading suspect in epidemics of allergic, inflammatory and autoimmune diseases associated with post-industrial culture.
Immunity in wild and laboratory rats has been used as a model for immunity in biomenormal and biome depleted environments, respectively.
In this study, the ranges of numerous immune parameters (such as cytokine production and cell surface marker expression) in 8 wild rats overlapped with the ranges found in 7 laboratory rats.
However, considering a number of parameters simultaneously as an “expression index” revealed a substantially greater range of immune activity in the wild compared with laboratory rats.
These findings are consistent with the intuitive idea that the immune system is inherently malleable or flexible within environments of evolutionary adaptedness, and might suggest that biome reconstitution as an effective therapy could be achieved in a variety of ways.
American Psychological Association (APA)
Lin, Shu S.& Holzknecht, Zoie E.& Trama, Ashley M.& Everett, Mary Lou& Thomas, Anitra D.& Su, Kuei-Ying…[et al.]. 2013. Immune characterization of wild-caught rattus norvegicus suggests diversity of immune activity in biome-normal environments. Journal of Evolutionary Medicine،Vol. 1, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-685942
Modern Language Association (MLA)
Lin, Shu S.…[et al.]. Immune characterization of wild-caught rattus norvegicus suggests diversity of immune activity in biome-normal environments. Journal of Evolutionary Medicine Vol. 1 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-685942
American Medical Association (AMA)
Lin, Shu S.& Holzknecht, Zoie E.& Trama, Ashley M.& Everett, Mary Lou& Thomas, Anitra D.& Su, Kuei-Ying…[et al.]. Immune characterization of wild-caught rattus norvegicus suggests diversity of immune activity in biome-normal environments. Journal of Evolutionary Medicine. 2013. Vol. 1, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-685942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 15-16
Record ID
BIM-685942